Human HLA-DRB1 Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11640AFP680

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FAB11640AFP680-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1091354

View all HLA-DRB1 Antibodies »

Product Specifications

Immunogen

Synthetic Peptide

Specificity

Detects a synthetic peptide specific for human HLA-DRB1 around amino acid 45 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: HLA-DRB1

HLA-DRB1 is an HLA class II histocompatibility antigen. It is part of a heterodimer consisting of an alpha (DRA) and a beta chain (DRB) which are both anchored in the membrane. Class II molecules are constitutively expressed in professional APC's. HLA-II is an important immune system protein that plays a role in tumor antigen presentation, immune response, and immune surveillance. HLA-DRB1 presents antigenic peptides to HLA-DRB1-restricted CD4+ T-cells. Aberrant expression of HLA-II is closely related to the pathogenesis of tumors.

References

  1. "Entrez Gene:  HLA-DRB1 major histocompatibility complex, Class II, DR beta I"
  2. Hu JM, Li L, Chen YZ, Liu C, Cui X, Yin L, Yang L, Zou H, Pang L, Zhao J, Qi Y, Cao Y, Jiang J, Liang W, Li F. HLA-DRB1 and HLA-DQB1 methylation changes promote the occurrence and progression of Kazakh ESCC. Epigenetics. 2014 Oct;9(10):1366-73. doi: 10.4161/15592294.2014.969625. PMID: 25437052; PMCID: PMC4623353.
  3. Zhao X, Li J, Zhu Q, Liang G, Xia W, He X, Zhu C, Qi H, Deng B, Chen X, Zhang J. HLA-A and HLA-DRB1 may play a unique role in ovarian teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis. Reprod Biol Endocrinol. 2020 Nov 7;18(1):107. doi: 10.1186/s12958-020-00661-5. PMID: 33160385; PMCID: PMC7648266.

Long Name

Major histocompatibility complex, class II, DR beta 1

Alternate Names

DRB1, HLA-DR1B, HLA-DRB, SS1

Entrez Gene IDs

3123 (Human)

Gene Symbol

HLA-DRB1

UniProt

P01911 (Human)

Additional HLA-DRB1 Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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