Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1120264)

View all FUS Antibodies »

Product Specifications

Immunogen

E. coli - derived recombinant human FUS

Specificity

Detects recombinant human FUS and human TAF-15 in Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human FUS Alexa Fluor™ Plus 647-conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FUS

Fused in sarcoma (FUS) is a multifunctional RNA-binding protein with a molecular weight of approximately 68 kDa. FUS belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs) and plays critical roles in RNA metabolism, including RNA splicing, transport, translation, and stability. Beyond its functions in RNA handling, FUS contributes to DNA damage repair and transcription regulation, highlighting its importance in cellular homeostasis. FUS is ubiquitously expressed across various tissues, with predominant localization in the nucleus; however, its mislocalization to the cytoplasm is directly implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in the FUS gene have been identified as causative factors in familial ALS, where altered FUS protein function contributes to protein aggregation and neuronal toxicity. Additionally, FUS is involved in cellular stress responses, forming dynamic assemblies known as stress granules under adverse conditions. Aberrant FUS expression or activity has garnered attention as a key biomarker for neurodegenerative disorders and a promising target for therapeutic interventions.

References

  1. Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science. 2009 Feb 27;323(5918):1208-1211. doi: 10.1126/science.1165942. PMID: 19251628; PMCID: PMC4516382. 
  2. Sama RR, Ward CL, Bosco DA. Functions of FUS/TLS from DNA repair to stress response: implications for ALS. ASN Neuro. 2014 Jun 1;6(4):1759091414544472. doi: 10.1177/1759091414544472. PMID: 25289647; PMCID: PMC4189536. 
  3. Yang S, Warraich ST, Nicholson GA, Blair IP. Fused in sarcoma/translocated in liposarcoma: a multifunctional DNA/RNA binding protein. Int J Biochem Cell Biol. 2010 Sep;42(9):1408-11. doi: 10.1016/j.biocel.2010.06.003. Epub 2010 Jun 10. PMID: 20541619.

Long Name

FUS RNA binding protein

Alternate Names

ALS6, altFUS, ETM4, FUS1, HNRNPP2, POMP75, TLS

Entrez Gene IDs

2521 (Human); 233908 (Mouse); 317385 (Rat)

Gene Symbol

FUS

UniProt

P35637 (Human)

Additional FUS Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human FUS Alexa Fluor™ Plus 647-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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