Human FUBI/MNSF beta Alexa Fluor™ Plus 405-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB9036AFP405

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FAB9036AFP405-100UG
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunocytochemistry

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Monoclonal Rat IgG2B Clone # 861504

View all FUBI/MNSF beta Antibodies »

Product Specifications

Immunogen

E.coli-derived recombinant human FUBI/MNSF beta

Specificity

Detects human FUBI in direct ELISAs.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2B

Applications

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: FUBI/MNSF beta

The ubiquitin-like protein FUBI/ MNSF beta (Monoclonal Nonspecific Suppressor Factor Beta) is encoded by the FAU gene, and is translated as a pro-form consisting of FUBI fused to the ribosomal S30 protein. S30 is cleaved in a post-translational reaction, releasing the mature 74 amino acid FUBI/MNSF beta protein. FUBI has a
C-terminal gly-gly motif common to many ubiquitin-like proteins.  FUBI/ MNSF beta conjugation to Bcl-G has been shown to regulate the ERK1/2-MAPK cascade in macrophage cell lines, and may be implicated in TLR4-mediated signal transduction. Conjugation to endophilin II regulates dectin-1-mediated phagocytosis and inflammatory responses, and may be implicated in TLR2 signaling pathway.

References

  1. Rossman,T.G. et al. (2003) Oncogene 22:1817.
  2. Nakamura, M. & Omura, S. (2008) Biosci. Biotech. Biochem. 72:1915.
  3. Nakamura, M. & Yamaguchi, S. (2006) J. Biol. Chem. 281:16861.
  4. Nakamura, M & Watanabe, N. (2010) Biochem, Biophys. Res. Comm. 15:275.
  5. Nakamura, M. et al. (2012) Mol. Cell Biochem. 364:39.

Alternate Names

40S Ribosomal Protein S30, asr1, FAU, Fub1, MNSFbeta, RPS30, S30

Entrez Gene IDs

2197 (Human); 100039316 (Mouse); 29752 (Rat)

Gene Symbol

FAU

UniProt

P35544

Additional FUBI/MNSF beta Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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