Human CRHR-1 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB3930

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Mouse, Hamster - Cricetulus (Chinese Hamster)

Applications

Validated:

Immunohistochemistry, Flow Cytometry, CyTOF-ready

Cited:

Immunohistochemistry, Immunocytochemistry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 343919

View all CRHR1 Antibodies »

Product Specifications

Immunogen

NS0 mouse myeloma cell line transfected with human CRHR-1
Ser24-Val415
Accession # NP_004373

Specificity

Detects human CRHR‑1 transfectants but not irrelevant transfectants.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human CRHR-1 Antibody

Application
Recommended Usage

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

2.5 µg/106 cells
Sample: Human CRHR‑1 transfected Ba/F3 cells

Immunohistochemistry

8-25 µg/mL
Sample: Immersion fixed paraffin-embedded sections of human placenta

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CRHR1

Corticotrophin-Releasing Hormone Receptor 1 (CRHR-1), also known as CRFR-1, is a 7TM protein that belongs to the G protein-coupled receptor family 2. CRHR-1 is expressed in the brain and adrenal gland where it mediates corticotropin-induced effects on anxiety, depression, and stress-associated pathologies. The immunogen for this antibody corresponds to one of the four alternately spliced forms and has a 29 amino acid deletion in the first cytoplasmic domain. Human CRHR-1 shares 97% amino acid sequence identity with mouse and rat CRHR-1.

Long Name

Corticotropin Releasing Hormone Receptor 1

Alternate Names

CHR-R1, CRF1, CRFR, CRFR1

Entrez Gene IDs

1394 (Human); 12921 (Mouse)

Gene Symbol

CRHR1

UniProt

NP_004373

Additional CRHR1 Products

Product Documents for Human CRHR-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human CRHR-1 Antibody

For research use only

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