Cyclophilin B Antibody (CL3915) - BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-59782
![Western Blot: Cyclophilin B Antibody (CL3915) [NBP2-59782]](https://resources.bio-techne.com/images/products/Cyclophilin-B-Antibody-5479-Western-Blot-NBP2-59782-img0003.jpg "Western Blot: Cyclophilin B Antibody (CL3915) [NBP2-59782]")
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Validated by
Knockout/Knockdown
Species Reactivity
Human, Mouse, Rat
Applications
Western Blot, Knockdown Validated
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG2B Clone # CL3915
Format
BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
This antibody was developed using a synthetic peptide derived from P23284, with the exact immunogen sequence remaining proprietary.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG2B
Scientific Data Images for Cyclophilin B Antibody (CL3915) - BSA Free
Western Blot: Cyclophilin B Antibody (CL3915) [NBP2-59782]
Western Blot: Cyclophilin B Antibody (5479) [NBP2-59782] - Analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-PPIB antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.![Western Blot: Cyclophilin B Antibody (CL3915) [NBP2-59782]](https://resources.bio-techne.com/images/products/Cyclophilin-B-Antibody-5479-Western-Blot-NBP2-59782-img0001.jpg "Western Blot: Cyclophilin B Antibody (CL3915) [NBP2-59782]")
Western Blot: Cyclophilin B Antibody (CL3915) [NBP2-59782]
Western Blot: Cyclophilin B Antibody (5479) [NBP2-59782] - Analysis in human cell line HeLa, human cell line HEK 293, human cell line A-431, human cell line HepG2, mouse cell line NIH-3T3 and rat cell line NBT-II.Applications for Cyclophilin B Antibody (CL3915) - BSA Free
Application
Recommended Usage
Western Blot
1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
PBS (pH 7.2) and 40% Glycerol
Format
BSA Free
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: Cyclophilin B
Cyclophilin B (SCYLP, CyPB and peptidyl-prolyl cis-trans isomerase B) is a 24 kDa glycoprotein member of the B subfamily of the cyclophilin-type PPIase family of molecules. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones. The human Cyclophilin B precursor is 216 amino acids (aa) in length. It contains a 25 aa signal sequence plus a 191 aa mature region. There is a partial heparin-binding sequence (aa 27-34), a PPIase domain (aa 47-204) and a C-terminal ER retention motif (aa 213-216). Over aa 34-216, the human and mouse sequences are 95% aa identical.
Alternate Names
CYP-S1, CYPB, PPIB, S-cyclophilin, SCYLP
Gene Symbol
PPIB
Additional Cyclophilin B Products
Product Documents for Cyclophilin B Antibody (CL3915) - BSA Free
Product Specific Notices for Cyclophilin B Antibody (CL3915) - BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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