Cav1.2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-45988

Novus Biologicals, part of Bio-Techne
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NBP3-45988
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Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Cav1.2 Antibodies »

Product Specifications

Immunogen

calcium channel, voltage-dependent, L type, alpha 1C subunit. (Uniprot# Q13936)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Novus Biologicals Rabbit Cav1.2 Antibody - BSA Free (NBP3-45988) is a polyclonal antibody validated for use in IHC, WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Cav1.2 Antibody - BSA Free

Cav1.2 Antibody - BSA Free

Western Blot: Cav1.2 Antibody - BSA Free [NBP3-45988] -

Western Blot: Cav1.2 Antibody - BSA Free [NBP3-45988] - Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with (Cav1.2 Antibody) at dilution of 1:2000
Cav1.2 Antibody - BSA Free

Immunohistochemistry: Cav1.2 Antibody - BSA Free [NBP3-45988] -

Immunohistochemistry: Cav1.2 Antibody - BSA Free [NBP3-45988] - Immunohistochemistry of paraffin-embedded rat brain tissue slide using (Cav1.2 Antibody) at dilution of 1:200

Applications for Cav1.2 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50-1:500

Western Blot

1:1000-1:4000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Cav1.2

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on an ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (3). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (4, 5) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (5).

Long Name

Voltage-dependent L-type calcium channel subunit alpha-1C

Alternate Names

CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1

Gene Symbol

CACNA1C

Additional Cav1.2 Products

Product Documents for Cav1.2 Antibody - BSA Free

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Product Specific Notices for Cav1.2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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