5-HT2C Antibody (JA31-31)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-67100

Recombinant Monoclonal Antibody
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NBP2-67100
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Rat

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry Free-Floating

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JA31-31 expressed in HEK293

Concentration

1 mg/ml

View all 5-HT2C Antibodies »

Product Specifications

Immunogen

Synthetic peptide within Human 5-HT2C aa 409-458 / 458. (SwissProt: P28335 Human; SwissProt: P34968 Mouse; SwissProt: P08909 Rat)

Localization

Cell membrane.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for 5-HT2C Antibody (JA31-31)

Western Blot: 5-HT2C Antibody (JA31-31) [NBP2-67100]

Western Blot: 5-HT2C Antibody (JA31-31) [NBP2-67100]

Western Blot: 5-HT2C Antibody (JA31-31) [NBP2-67100] - Analysis of 5HT2C Receptor on A431 (1) and K562 (2) lysate using anti-5HT2C Receptor antibody at 1/1,000 dilution.
Immunohistochemistry-Paraffin: 5-HT2C Antibody (JA31-31) [NBP2-67100]

Immunohistochemistry-Paraffin: 5-HT2C Antibody (JA31-31) [NBP2-67100]

Immunohistochemistry-Paraffin: 5-HT2C Antibody (JA31-31) [NBP2-67100] - Analysis of paraffin-embedded mouse brain tissue using anti-5HT2C Receptor antibody. Counter stained with hematoxylin.
5-HT2C Antibody (JA31-31) Western Blot: 5-HT2C Antibody (JA31-31) [NBP2-67100]

Western Blot: 5-HT2C Antibody (JA31-31) [NBP2-67100]

Western blot analysis on different lysates with NBP2-67100 at 1/1,000 dilution. Lane 1: K-562 cell lysate (15 µg/Lane) Lane 2: SH-SY5Y cell lysate (15 µg/Lane) Lane 3: Human brain tissue lysate (30 µg/Lane) Predicted band size: 52 kDa Observed band size: 70 kDa Exposure time: 1 minute 2 seconds; 4-20% SDS-PAGE gel. Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. NBP2-67100 at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG [HRP] Secondary Antibody at 1/50,000 dilution was used for 1 hour at room temperature.

Applications for 5-HT2C Antibody (JA31-31)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS (pH7.4), 0.05% BSA, 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: 5-HT2C

Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesised in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract. Serotonin plays an important part in the biochemistry of depression, migraine, bipolar disorder and anxiety. It is also believed to be influential on sexuality and appetite. 5-HT is generally thought not to be released from synaptic terminal buttons in the manner of classical neurotransmission but from serotonergic varacosities into the extra neuronal space. From here it is free to diffuse over a relatively large region of space (>20um) and activate 5-HT receptors located on the dendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergic action is terminated primarily via uptake of 5-HT from the synapse. This is through the specific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynaptic neuron. The pharmacology of 5-HT is extremely complex, with its actions being mediated by a large and diverse range of 5-HT receptors.

Long Name

5-Hydroxytryptamine Receptor 2C

Alternate Names

5-HTR2C, 5HT2C, HTR2C, Serotonin Receptor 2C

Gene Symbol

HTR2C

Additional 5-HT2C Products

Product Documents for 5-HT2C Antibody (JA31-31)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for 5-HT2C Antibody (JA31-31)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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