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Synthetic Metalloprotease Inhibitors: Small Molecules and Peptides

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

23 results for "Synthetic Metalloprotease Inhibitors Small Molecules and Peptides" in Products

Synthetic Metalloprotease Inhibitors: Small Molecules and Peptides

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

23 results for "Synthetic Metalloprotease Inhibitors Small Molecules and Peptides" in Products

Broad-spectrum MMP inhibitor; tetracycline derivative

Potent ADAM10 and ADAM17 inhibitor

Antibiotic. Displays neuroprotective effects

Broad spectrum MMP inhibitor

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Broad spectrum MMP inhibitor

Selective inhibitor of MMP-2

Selective inhibitor of MMP-13

Broad spectrum MMP inhibitor

Potent, broad spectrum MMP inhibitor

Potent MMP inhibitor

High affinity and selective MMP2 inhibitor

Pro-MMP9 activation inhibitor

Highly potent and selective MMP13 inhibitor

Potent and selective inhibitor of MMP-13

Potent and selective BMP-1 (PCP) inhibitor

ADAM-17 (TACE) and MMP inhibitor

ADAM-17 (TACE) and MMP inhibitor

ADAM-17 (TACE) and MMP inhibitor

Highly selective MMP-3 and MMP-12 inhibitor

Inhibitor of MMP-2

Selective ADAM10 metalloprotease inhibitor

Histone deacetylase inhibitor

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