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53 results for "e3 ligase inhibitors" in Products

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53 results for "e3 ligase inhibitors" in Products

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Catalog #: 7178

Functionalized IAP ligand for PROTACs

Chemical Name : tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity : ≥95% (HPLC)
Degrader Building Blocks Small Molecule
Catalog #: 6471

Functionalized IAP ligand for PROTACs

Chemical Name : tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride
Purity : ≥98% (HPLC)
Degrader Building Blocks Small Molecule

HECT E3 ubiquitin ligase inhibitor

Chemical Name : N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity : ≥98% (HPLC)
Ubiquitin Ligase (E3) Inhibitors Small Molecule
Catalog #: 7498

SPOP E3 ubiquitin ligase inhibitor

Chemical Name : 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide
Purity : ≥98% (HPLC)
Ubiquitin Ligase (E3) Inhibitors Small Molecule
Catalog #: 5636

β-TrCP1 ligase inhibitor

Chemical Name : 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Purity : ≥98% (HPLC)
Ubiquitin Ligase (E3) Inhibitors Small Molecule
Catalog #: 6075

MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)

Chemical Name : 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Purity : ≥97% (HPLC)
Ubiquitin Ligase (E3) Inhibitors Small Molecule
Catalog #: 6948

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name : (2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity : ≥96% (HPLC)
Active Degraders Small Molecule

(+)-JQ1 based Degrader (PROTAC®) that selectively degrades BRD4

Chemical Name : (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity : ≥98% (HPLC)
Active Degraders Small Molecule

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Chemical Name : 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
Purity : ≥98% (HPLC)
Ubiquitin Ligase (E3) Inhibitors Small Molecule
Catalog #: 6305

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name : 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity : ≥98% (HPLC)
Ubiquitin Ligase (E3) Inhibitors Small Molecule
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