53 results for "e3 ligase inhibitors" in Products

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Catalog #: 5433

HECT E3 ubiquitin ligase inhibitor

Chemical Name :	N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity :	≥98% (HPLC)

Catalog #: 4375

Selective inhibitor of E3 ubiquitin ligase

Chemical Name :	9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Purity :	≥98% (HPLC)

Catalog #: 6466

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name :	2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
Purity :	≥98% (HPLC)

Catalog #: 6327

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name :	(6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity :	≥98% (HPLC)

Catalog #: 5636

β-TrCP1 ligase inhibitor

Chemical Name :	4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
Purity :	≥98% (HPLC)

Catalog #: 6305

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name :	3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity :	≥98% (HPLC)

Catalog #: 6154

(+)-JQ1 based Degrader (PROTAC®) that selectively degrades BRD4

Chemical Name :	(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity :	≥98% (HPLC)