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Fetal Bovine Serum

Fetal bovine serum (FBS), also known as fetal calf serum (FCS), is a versatile and widely used cell growth supplement. The significantly lower content of antibodies compared to adult and newborn sera minimizes the risk of antibody cross reaction with cells in culture. FBS provides a high level of nutrients and an optimal combination of growth factors, making it a highly effective cell growth promoter for virtually any cell culture system.

 

Optima grade fetal bovine serum – US origin

If you are looking for Atlanta Biologicals FBS, learn about how Atlanta Biologicals is now R&D Systems, a Bio-Techne brand.

Standard and specialty FBS grades – USDA approved

Which FBS is Best for Your Cells?

This article outlines the various standard and specialty grades of FBS, their benefits, and specifications.

Article on why FBS consistency matters

Why Serum Consistency Matters to Cell Culture Health

This article discusses key quality parameters to consider when sourcing your FBS, and it provides data illustrating the 40-year historical consistency of our FBS products.

Standard Grades of Fetal Bovine Serum (FBS)

To meet your cell culture requirements, these grades of fetal bovine serum will support a broad spectrum of culture needs. All standard grades of fetal bovine serum are also available heat inactivated.

Grade of Fetal Bovine Serum Material Origin Additional Features Heat Inactivated Available? Gamma Irradiated Available?
Premium Grade Fetal Bovine Serum USDA-approved FBS The most affordable grade of fetal bovine serum. Yes  
Optima Grade Fetal Bovine Serum US Origin FBS, USDA-Aphis certified Additional extensive biochemical profile and extended virus testing to provide peace of mind for our serum users. This serum grade also includes a comprehensive quality assurance testing. Yes Yes
Premium Select Grade Fetal Bovine Serum USDA-approved FBS The highest quality FBS grade. Premium Select sera are screened with additional hormone profiling, biochemical analysis, and rigorous viral testing for specific research applications requiring this data. Yes Yes

Specialty Grades of Fetal Bovine Serum (FBS)

These grades of FBS are selected for specialty cell culture applications such as embryonic stem cell cultures, hybridoma technology, TET systems and cell lines, and more. All specialty grades of fetal bovine serum are also available heat inactivated.

Specialty Fetal Bovine Serum Material Origin Additional Features Heat Inactivated Available?
Embryonic Stem Cell Qualified Fetal Bovine Serum USDA-approved FBS Removes the need for time-consuming pre-screening of multiple lots of serum. This specialty fetal bovine serum ensures stability when culturing embryonic stem cells by screening for plating efficiency, colony morphology, and cytotoxicity, while also maintaining cells in their undifferentiated state. Yes
Hybridoma Qualified Fetal Bovine Serum USDA-approved FBS Designed for the culture of hybridoma and myeloma cells. This specialty FBS has been screened to show superior growth at limiting dilutions and lack of cytotoxicity in growth studies. Yes
TET Tested Fetal Bovine Serum USDA-approved FBS Designed for use in TET-driven gene expression systems and cell lines. Only lots with undetectable TET levels throughout serum production are selected as TET Tested Fetal Bovine Serum. Yes
Charcoal/Dextran Treated Fetal Bovine Serum US Origin FBS, USDA-approved FBS Designed for use in cultures requiring lower levels of hormones, steroids, or growth factors in serum such as paracrine and endocrine signaling. This specialty FBS is screened for multiple hormones and steroids before and after treatment. Yes
Dialyzed Fetal Bovine Serum US Origin FBS Designed for use in cell culture systems requiring reduced concentrations of low molecular weight components such as nucleotides, amino acids, hormones, salts, and small proteins. This serum is dialyzed against physiological saline using a 12 – 14 kDa cutoff membrane using a controlled process where glucose concentration is precisely monitored throughout the procedure. Exhaustive dialysis is not performed in order to prevent precipitation and inactivation of serum peptides. Yes
Gamma Irradiated Fetal Bovine Serum US Origin and USDA-approved Gamma irradiation is an effective method of inactivating viruses and other adventitious agents that may exist at low levels in serum. Gamma irradiated Optima and Premium Select FBS are exposed to a cobalt source, delivered at a dose of 25-40 kGy, which removes up to 6 logs of contaminating biological agents, while preserving the growth performance characteristics of serum. Gamma irradiated FBS offers greater assurance that the existence of low-level microbial contamination is reduced and the risks associated with animal-derived components are minimized. Yes

FBS Quality

The quality FBS of has a vital impact on many cell culture technologies. You can expect the highest quality of USDA APHIS-certified, US Origin, and USDA-approved FBS which we manufacture at our ISO 9001:2105 certified facility. An established network of raw materials supply allows us to maintain direct control of all manufacturing processes.

Background Information