Zardaverine

Name: Zardaverine
Brand: Tocris Bioscience
SKU: 1046

Tocris Bioscience a Bio-Techne Brand

Catalog # 1046

Citations (4)

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Key Product Details

Description:	PDE3/4 inhibitor
Chemical Name:	6-[4-(Difluoromethoxy)-3-methoxyphenyl]-3(2H)-pyridazinone
Purity:	≥98% (HPLC)
Molecular Weight:	268.22

View Full Technical Details for Zardaverine

Biological Activity for Zardaverine

Zardaverine is a phosphodiesterase inhibitor, selective for PDE3 and 4 (IC₅₀ values are 0.5 and 0.8 μM respectively).

Technical Data for Zardaverine

M. Wt	268.22
Formula	C₁₂H₁₀F₂N₂O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	101975-10-4
PubChem ID	5723
InChi Key	HJMQDJPMQIHLPB-UHFFFAOYSA-N
Smiles	COC1=C(OC(F)F)C=CC(=C1)C1=NNC(=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zardaverine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Zardaverine

The following data is based on the product molecular weight 268.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.73 mL	18.64 mL	37.28 mL
5 mM	0.75 mL	3.73 mL	7.46 mL
10 mM	0.37 mL	1.86 mL	3.73 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

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Reconstitution Calculator

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References for Zardaverine

References are publications that support the biological activity of the product.

Galvan and Schudt Actions of the phosphodiesterase inhibitor zardaverine on guinea pig ventricular muscle. Naunyn Schmiedebergs Arch.Pharmacol. 1990 PMID: 1700309
Kilian Is phosphodiesterase inhibition a relevant bronchospasmolytic principle? Agents Actions Suppl. 1989 PMID: 2683636

Citations for Zardaverine (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Zardaverine include:

Navarro et al. (2015) Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine. J Neurosci. 35:6639
PMID: 25926444
Lee et al. (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca²⁺ and cAMP. Nature. 492:123
PMID: 23143333
Gulyani et al. (2009) Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells. Exp Neurol. 215:236
PMID: 19013457
Zerani et al. (2004) Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea. Pain. 183:279
PMID: 15531716

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