ZAPA sulfate

Name: ZAPA sulfate
Brand: tocris
SKU: 0180

Catalog # 0180

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	'Low affinity' GABA_A agonist; also GABA_A-ρ antagonist
Chemical Name:	(Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid sulfate
Molecular Weight:	244.24

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Technical Data
Citations (1) / Reviews

Biological Activity

More potent than either GABA or muscimol as an agonist at low affinity GABA_A receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. Also a GABA_A-ρ receptor antagonist.

Technical Data

M. Wt	244.24
Formula	C₄H₆N₂O₂S.H₂SO₄
Storage	Store at RT
CAS Number	371962-01-5
PubChem ID	90479730
InChi Key	UWVNHPNVOMFDHW-ODZAUARKSA-N
Smiles	OS(O)(=O)=O.NC(=N)S\C=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		10

Preparing Stock Solutions

The following data is based on the product molecular weight 244.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	40.94 mL	204.72 mL	409.43 mL
0.5 mM	8.19 mL	40.94 mL	81.89 mL
1 mM	4.09 mL	20.47 mL	40.94 mL
5 mM	0.82 mL	4.09 mL	8.19 mL

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References

References are publications that support the biological activity of the product.

Allan Isothiouronium compounds as γ-aminobutyric acid agonists. Br.J.Pharmacol. 1986 PMID: 3015310
Holden-Dye and Walker ZAPA, (Z)-3-[(aminoiminomethyl)thio]-2-propenoic acid hydrochloride, a potent agonist at GABA-receptors on the Ascaris muscle cell. Br.J.Pharmacol. 1988 PMID: 2851353
Johnston GABA_C receptors: relatively simple transmitter-gated ion channels? TiPS 1996 PMID: 8885697

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for ZAPA sulfate include:

Asiedu et al. (2012) Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. J Pain. 13:546
PMID: 22537560

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Product Datasheets

COA

Certificate of Analysis

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ZAPA sulfate

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Key Product Details

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

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