ω-Conotoxin MVIIC

Name: ω -Conotoxin MVIIC
Brand: Tocris Bioscience
SKU: 1084
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1084

Citations (11)

(1)

COA / SDS

Discontinued Product

1084 has been discontinued. View all Cav2.x Channel Blockers products.

Key Product Details

Description:	Ca_V2.x blocker
Molecular Weight:	2749

View Full Technical Details for ω-Conotoxin MVIIC

Biological Activity for ω-Conotoxin MVIIC

ω-Conotoxin MVIIC is a peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.

Licensing Information

Sold under license from the University of Utah.

Technical Data for ω-Conotoxin MVIIC

M. Wt	2749
Formula	C₁₀₆H₁₇₈N₄₀O₃₂S₇
Single Letter Sequence	CKGKGAPCRKTMYDCCSGSCGRRGKC (Modifications: Disulfide bridges: 1-16, 8-20, 15-26, Cys-26 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	147794-23-8
PubChem ID	90479752
InChi Key	FHVUTHWUIUXZBY-IXEXBNPISA-N
Smiles	[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ω-Conotoxin MVIIC

Solubility

Soluble to 1mg/ml in water

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References for ω-Conotoxin MVIIC

References are publications that support the biological activity of the product.

McDonough Inhibition of Ca²⁺ channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J.Neurosci. 1996 PMID: 8786437
Hillyard A new conus peptide ligand for mammalian presynaptic Ca²⁺ channels. Neuron 1992 PMID: 1352986

Citations for ω-Conotoxin MVIIC (11)

Showing 1 - 10 of 11 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for ω-Conotoxin MVIIC include:

Pascual-Caro et al. (2018) STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca²⁺ entry. J Mol Med (Berl). 96:1061
PMID: 30088035
Fortalezas et al. (2018) Methyl-β-Cyclodextrin Impairs the Phosphorylation of the β₂ Subunit of L-Type Calcium Channels and Cytosolic Calcium Homeostasis in Mature Cerebellar Granule Neurons. Int J Mol Sci. 19
PMID: 30463327
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One. 12(9):e0184261
PMID: 28877214
Luca et al. (2017) Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents. Neuron. 95:63
PMID: 28683270
Hanlon et al. (2016) Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press). 8:59
PMID: 27186076
Pan et al. (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. PLoS One. 350:290
PMID: 24891452
Schöbel et al. (2014) Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses. 39:471
PMID: 24718416
Smith et al. (2013) Comparative functional expression of nAChR subtypes in rodent DRG neurons. Front Cell Neurosci. 7:225
PMID: 24348328
Schöbel et al. (2012) Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS One. 7:e48005
PMID: 23144843
Maier et al. (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem. 285:35606
PMID: 20826795
Haeberle et al. (2008) Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. Nat Commun. 3:e1750
PMID: 18454189

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Showing 1 - 10 of 11 citations Showing All

Customer Reviews for ω-Conotoxin MVIIC (1)

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breast cancer cell viability by a cannabinoid receptor 2 agonist

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: MCF-7

We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076

PMID: 27186076

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