W-84 dibromide

Name: W-84 dibromide
Brand: tocris
SKU: 0532
Rating: 4 (1 reviews)

Catalog # 0532

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Key Product Details

Description:	Stabilizer of cholinergic antagonist-receptor complexes
Chemical Name:	Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide
Molecular Weight:	708.53

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Technical Data
Citations / Reviews (1)

Biological Activity

Stabilizes cholinergic antagonist-receptor complexes by an allosteric effect. Increases the protective effect of atropine against organophosphate poisoning.

Technical Data

M. Wt	708.53
Formula	C₃₂H₄₄Br₂N₄O₄
Storage	Store at RT
CAS Number	21093-51-6
PubChem ID	167961
InChi Key	DZRJZDQAGMZGGA-UHFFFAOYSA-L
Smiles	O=C1N(CCC[N+](C)(C)CCCCCC[N+](C)(C)CCCN(C(C4=C3C=CC=C4)=O)C3=O)C(C2=C1C=CC=C2)=O.[Br-].[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.08	10

Preparing Stock Solutions

The following data is based on the product molecular weight 708.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.11 mL	70.57 mL	141.14 mL
0.5 mM	2.82 mL	14.11 mL	28.23 mL
1 mM	1.41 mL	7.06 mL	14.11 mL
5 mM	0.28 mL	1.41 mL	2.82 mL

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References

References are publications that support the biological activity of the product.

Jepsen Allosteric stabilisation of [³H]-N-methylscopolamine binding in guinea pig myocardium by an antidote against organophosphate intoxication. Pharmacol.Toxicol. 1988 PMID: 3054859
Mitchelson Antimuscarinic action of an alkane-bis ammonium compound alone and in combination with (+)-bensetimide. Eur.J.Pharmacol. 1975 PMID: 1242377
Mohr Equipotent allosteric effect of W84 on [³H]-NMS binding to cardiac muscarinic receptors from guinea-pig, rat and pig. Pharmacol.Toxicol. 1992 PMID: 1579545

Citations

Currently there are no citations for W-84 dibromide.

Customer Reviews (1)

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HPLC Pharmacokinetic assay

Name: Abhijit Nirwane

Species: Mouse

Assay Type: In Vivo

Purity is excellent.

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