W-13 hydrochloride

Name: W-13 hydrochloride
Brand: Tocris Bioscience
SKU: 0361
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0361

Citations (2)

(1)

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Key Product Details

Description:	Calmodulin antagonist
Chemical Name:	N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	349.27

View Full Technical Details for W-13 hydrochloride

Biological Activity for W-13 hydrochloride

W-13 hydrochloride is a calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC₅₀ of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.

Technical Data for W-13 hydrochloride

M. Wt	349.27
Formula	C₁₄H₁₇ClN₂O₂S.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	88519-57-7
PubChem ID	16760706
InChi Key	QKAALLVQBOLELJ-UHFFFAOYSA-N
Smiles	Cl.NCCCCNS(=O)(=O)C1=CC=C2C(Cl)=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for W-13 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	34.93	100
	DMSO	34.93	100

Preparing Stock Solutions for W-13 hydrochloride

The following data is based on the product molecular weight 349.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.86 mL	14.32 mL	28.63 mL
5 mM	0.57 mL	2.86 mL	5.73 mL
10 mM	0.29 mL	1.43 mL	2.86 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for W-13 hydrochloride

References are publications that support the biological activity of the product.

Bosch Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21^cip1. J.Biol.Chem. 1998 PMID: 9705360
Stroble and Peterson Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pim. and the calmodulin antagonist, W-13. J.Pharmacol.Exp.Ther. 1992 PMID: 1403784
Hidaka and Tanaka Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 1983 PMID: 6139736

Citations for W-13 hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for W-13 hydrochloride include:

Yanda et al. (2017) Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease. J Biol Chem. 292:17897
PMID: 28887310
Sethna et al. (2016) Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression. J Neurosci Res. 94:401
PMID: 26864654

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Customer Reviews for W-13 hydrochloride (1)

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PN and PH cells were treated with W-7 (catalog no. 0369) and W-13 (catalog no. 0361) purchased from Tocris.

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: PN and PH cells

PN and PH cells were treated with W-7 (catalog no. 0369) and W-13(catalog no. 0361) purchased from Tocris.

PMID: 28887310

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