TT 232

Tocris Bioscience a Bio-Techne Brand

Catalog # 4639

COA / SDS

Discontinued Product

4639 has been discontinued. View all Somatostatin Receptor Agonists products.

Key Product Details

Description:	sst₁ and sst₄ agonist
Molecular Weight:	947.13

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Biological Activity for TT 232

TT 232 is a peptide agonist for sst₁/sst₄ somatostatin receptors. Somatostatin analog; inhibits tyrosine kinase activity in human colon tumor cell lines. Demonstrates an antiproliferative effect both in vitro and in vivo and induces apoptosis in a pancreatic tumor cell line. Does not inhibit growth hormone release or secretion.

Technical Data for TT 232

M. Wt	947.13
Formula	C₄₅H₅₈N₁₀O₉S₂
Single Letter Sequence	fCYwKCT (Modifications: Disulfide bridge between 2 - 6; Thr-7 = C-terminal amide)
Storage	Store at -20°C
CAS Number	147159-51-1
PubChem ID	6918265
InChi Key	SNAJPQVDGYDQSW-DYCFWDQMSA-N
Smiles	[H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TT 232

Solubility

Soluble to 1mg/ml in water

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References for TT 232

References are publications that support the biological activity of the product.

Elekes Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse. Eur.J.Pharmacol. 2008 PMID: 17961545
Tejeda Evaluation of the antitumor efficacy of the somatostatin structural derivative TT-232 on different tumor models. Anticancer Res. 2006 PMID: 17094470
Kéri A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity. Proc.Natl.Acad.Sci.U.S.A. 1996 PMID: 8901613

Citations for TT 232

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TT 232

Tocris Bioscience a Bio-Techne Brand

Key Product Details

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Biological Activity for TT 232

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References for TT 232

Citations for TT 232

Product Documents for TT 232

COA

Certificate of Analysis

SDS

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