TRIM

Name: TRIM
Brand: tocris
SKU: 0919

Catalog # 0919

Citations (1)

Datasheet / COA / SDS

Discontinued Product

0919 has been discontinued. View all Additional NOS Inhibitors products.

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Key Product Details

Description:	nNOS/iNOS inhibitor
Chemical Name:	1-(2-Trifluoromethylphenyl)imidazole
Purity:	≥99% (HPLC)
Molecular Weight:	212.17

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Biological Activity

A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC₅₀ values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.

Technical Data

M. Wt	212.17
Formula	C₁₀H₇F₃N₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	25371-96-4
PubChem ID	1359
InChi Key	WZBWBNCQUTXYEL-UHFFFAOYSA-N
Smiles	FC(F)(F)C1=C(C=CC=C1)N1C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	21.22	100
	DMSO	10.61	50

Preparing Stock Solutions

The following data is based on the product molecular weight 212.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.71 mL	23.57 mL	47.13 mL
5 mM	0.94 mL	4.71 mL	9.43 mL
10 mM	0.47 mL	2.36 mL	4.71 mL
50 mM	0.09 mL	0.47 mL	0.94 mL

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References

References are publications that support the biological activity of the product.

Handy The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br.J.Pharmacol. 1995 PMID: 8581267
Handy Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects. Br.J.Pharmacol. 1996 PMID: 8886430
Tooker Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation. J.Neurosci. 2013 PMID: 24305814

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for TRIM include:

Zanardo et al. (1997) Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils. Proc Natl Acad Sci U S A. 94:14111
PMID: 9391161

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Product Datasheets

COA

Certificate of Analysis

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SDS

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TRIM

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References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

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