SU 6668

Tocris Bioscience a Bio-Techne Brand

Catalog # 3335

Citations (2)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	PDGFR, VEGFR and FGFR inhibitor
Alternative Names:	TSU68, Orantinib
Chemical Name:	5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	310.35

View Full Technical Details for SU 6668

Biological Activity for SU 6668

SU 6668 is an ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC₅₀ values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC₅₀ values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

Technical Data for SU 6668

M. Wt	310.35
Formula	C₁₈H₁₈N₂O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	252916-29-3
PubChem ID	5329099
InChi Key	NHFDRBXTEDBWCZ-ZROIWOOFSA-N
Smiles	O=C2NC1=CC=CC=C1/C2=C/C3=C(C)C(CCC(O)=O)=C(C)N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SU 6668

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	31.03	100
	DMSO	31.03	100

Preparing Stock Solutions for SU 6668

The following data is based on the product molecular weight 310.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.11 mL	32.22 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SU 6668

References are publications that support the biological activity of the product.

Yamamoto TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res. 2008 PMID: 19047154
Laird SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. 2000 PMID: 10945623
Sun Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J.Med.Chem. 1999 PMID: 10602697

Citations for SU 6668 (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for SU 6668 include:

Yan et al. (2017) Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 7:45796
PMID: 28378824
Mathew et al. (2015) Feedback circuitry between miR-218 repression and RTK activation in glioblastoma. Mol Biol Cell. 8:ra42
PMID: 25943352

There are no citations that match your criteria.

Showing 1 - 2 of 2 citations Showing All

Product Documents for SU 6668

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.