Spiroxatrine

Name: Spiroxatrine
Brand: tocris
SKU: 0631

Catalog # 0631

Citations (1)

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Key Product Details

Description:	Potent α_2C antagonist
Chemical Name:	8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one
Molecular Weight:	379.46

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Biological Activity

5-HT_1A antagonist. More active and selective than spiperone. Also a very potent α_2C adrenergic receptor antagonist.

Technical Data

M. Wt	379.46
Formula	C₂₂H₂₅N₃O₃
Storage	Store at RT
CAS Number	1054-88-2
PubChem ID	5268
InChi Key	JVGBTTIJPBFLTE-UHFFFAOYSA-N
Smiles	O=C1NCN(C2=CC=CC=C2)C11CCN(CC2COC3=CC=CC=C3O2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.79	10

Preparing Stock Solutions

The following data is based on the product molecular weight 379.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.35 mL	131.77 mL	263.53 mL
0.5 mM	5.27 mL	26.35 mL	52.71 mL
1 mM	2.64 mL	13.18 mL	26.35 mL
5 mM	0.53 mL	2.64 mL	5.27 mL

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References

References are publications that support the biological activity of the product.

Bylund Pharmacological characteristics of α₂-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol.Pharmacol. 1992 PMID: 1353247
Nelson and Taylor Spiroxatrine: a selective serotonin 1A receptor antagonist. Eur.J.Pharmacol. 1986 PMID: 3720840
Schoeffter and Hoyer Centrally acting hypotensive agents with affinity for 5-HT_1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br.J.Pharmacol. 1988 PMID: 3207999

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Spiroxatrine include:

Moura et al. (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol. 149:1049
PMID: 17075569

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Spiroxatrine

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