Spaglumic acid

Name: Spaglumic acid
Brand: tocris
SKU: 0391

Catalog # 0391

Citations (2)

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Key Product Details

Description:	Selective mGlu₃ agonist
Alternative Names:	α-NAAG
Chemical Name:	N-Acetyl-L-aspartyl-L-glutamic acid
Purity:	≥96% (HPLC)
Molecular Weight:	304.26

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Biological Activity

The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu₃ receptors. Neuroprotective under non-hydrolysing conditions in vivo.

Technical Data

M. Wt	304.26
Formula	C₁₁H₁₆N₂O₈
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	3106-85-2
PubChem ID	188803
InChi Key	OPVPGKGADVGKTG-BQBZGAKWSA-N
Smiles	CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	30.43	100

Preparing Stock Solutions

The following data is based on the product molecular weight 304.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.43 mL	32.87 mL
5 mM	0.66 mL	3.29 mL	6.57 mL
10 mM	0.33 mL	1.64 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References

References are publications that support the biological activity of the product.

Neale N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 2000 PMID: 10899918
Thomas N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 2000 PMID: 10991955
Wroblewska N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 1997 PMID: 9202308

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for Spaglumic acid include:

Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Kolodziejczyk et al. (2009) The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain. 132:1496
PMID: 19383832

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Product Datasheets

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Certificate of Analysis

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Spaglumic acid

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Reconstitution Calculator

References

Citations (2)

Product Datasheets

COA

Certificate of Analysis

SDS

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