SKF 91488 dihydrochloride

Name: SKF 91488 dihydrochloride
Brand: tocris
SKU: 0512

Catalog # 0512

Datasheet / COA / SDS

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Key Product Details

Description:	Histamine N-methyltransferase inhibitor
Chemical Name:	4-(N,N-Dimethylamino)butylisothiourea dihydrochloride
Molecular Weight:	248.21

View Full Technical Details for SKF 91488 dihydrochloride

Technical Data
Citations / Reviews

Biological Activity

Homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.

Technical Data

M. Wt	248.21
Formula	C₇H₁₇N₃S.2HCl
Storage	Desiccate at RT
CAS Number	68941-21-9
PubChem ID	11957708
InChi Key	NPLHSMBWWIIWAQ-UHFFFAOYSA-N
Smiles	CN(CCCCSC(=N)N)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.62	75

Preparing Stock Solutions

The following data is based on the product molecular weight 248.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.37 mL	26.86 mL	53.72 mL
3.75 mM	1.07 mL	5.37 mL	10.74 mL
7.5 mM	0.54 mL	2.69 mL	5.37 mL
37.5 mM	0.11 mL	0.54 mL	1.07 mL

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References

References are publications that support the biological activity of the product.

Aiello Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089666
Beaven and Shaff New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 1979 PMID: 34400
Beaven and Shaff Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 1979 PMID: 161853
Ohuri Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 1992 PMID: 1534842

Citations

Currently there are no citations for SKF 91488 dihydrochloride.

Product Datasheets

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.