SKF 91488 dihydrochloride

Name: SKF 91488 dihydrochloride
Brand: Tocris Bioscience
SKU: 0512

Tocris Bioscience a Bio-Techne Brand

Catalog # 0512

COA / SDS

Discontinued Product

0512 has been discontinued. View all Methyltransferase Inhibitors products.

Key Product Details

Description:	Histamine N-methyltransferase inhibitor
Chemical Name:	4-(N,N-Dimethylamino)butylisothiourea dihydrochloride
Molecular Weight:	248.21

View Full Technical Details for SKF 91488 dihydrochloride

Biological Activity for SKF 91488 dihydrochloride

SKF 91488 dihydrochloride is a homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.

Technical Data for SKF 91488 dihydrochloride

M. Wt	248.21
Formula	C₇H₁₇N₃S.2HCl
Storage	Desiccate at RT
CAS Number	68941-21-9
PubChem ID	11957708
InChi Key	NPLHSMBWWIIWAQ-UHFFFAOYSA-N
Smiles	CN(CCCCSC(=N)N)C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SKF 91488 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.62	75

Preparing Stock Solutions for SKF 91488 dihydrochloride

The following data is based on the product molecular weight 248.21.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.37 mL	26.86 mL	53.72 mL
3.75 mM	1.07 mL	5.37 mL	10.74 mL
7.5 mM	0.54 mL	2.69 mL	5.37 mL
37.5 mM	0.11 mL	0.54 mL	1.07 mL

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Reconstitution Calculator

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References for SKF 91488 dihydrochloride

References are publications that support the biological activity of the product.

Aiello Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 1997 PMID: 9089666
Ohuri Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 1992 PMID: 1534842
Beaven and Shaff New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 1979 PMID: 34400
Beaven and Shaff Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 1979 PMID: 161853

Citations for SKF 91488 dihydrochloride

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Product Documents for SKF 91488 dihydrochloride

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.