ShK-Dap22

Name: ShK-Dap22
Brand: Tocris Bioscience
SKU: 3220
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 3220

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Key Product Details

Description:	Extremely potent and selective K_V1.3 blocker; suppresses T cell activation in vitro
Purity:	≥95% (HPLC)
Molecular Weight:	4012.7

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Biological Activity for ShK-Dap22

ShK-Dap22 is an extremely potent K_V1.3 channel blocker (K_d = 23 pM for mK_V1.3 currents). Selective for K_V1.3 over other mammalian potassium channels (IC₅₀ values are 23, 1800, 10500, 37000 and 39000 pM for mK_V1.3, mK_V1.1, hK_V1.6, mK_V1.4 and rK_V1.2 respectively, and >100000 pM for hK_V1.5, mK_V1.7, hK_V3.1, rK_V3.4 and hK_Ca4). Suppresses T cell activation in vitro (IC₅₀

Technical Data for ShK-Dap22

M. Wt	4012.7
Formula	C₁₆₆H₂₆₈N₅₄O₄₈S₇
Single Letter Sequence	RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC (Modifications: Disulfide bridges: 3-35, 12-28, 17-32, X= Dap)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	220384-25-8
PubChem ID	122187345
InChi Key	PFWOJTLVNOZSGQ-RIMJLNMDSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ShK-Dap22

Solubility

Soluble to 1mg/ml in water

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References for ShK-Dap22

References are publications that support the biological activity of the product.

Robbins Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via K_V1.3 channels. J.Physiol. 2005 PMID: 15677684
Kalman ShK-Dap²², a potent K_V1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 1998 PMID: 9830012

Citations for ShK-Dap22

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Customer Reviews for ShK-Dap22 (1)

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Great product with reproducible data

Name: Sadequl Islam

Species: Human

Assay Type: In Vitro

This compound was used in our cell culture lab to quantify blocking activity of Kv channels. It produced reproducible data in osteosarcoma cell line. Great product, hugely recommend.

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Product Documents for ShK-Dap22

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.