SCS

Name: SCS
Brand: Tocris Bioscience
SKU: 2143

Tocris Bioscience a Bio-Techne Brand

Catalog # 2143

Citations (2)

COA / SDS

Discontinued Product

2143 has been discontinued. View all GABA-A Receptor Antagonists products.

Key Product Details

Description:	Potent GABA_A antagonist; β1-subunit selective
Chemical Name:	Salicylidene salicylhydrazide
Molecular Weight:	256.26

View Full Technical Details for SCS

Biological Activity for SCS

SCS is a potent and selective partial inhibitor of β1-containing GABA_A receptors (IC₅₀ values are 4.5, 5.3 and 7.9 nM at α2β1γ1θ, α2β1γ1 and α2β1γ2s GABA_A receptors respectively). May bind allosterically to a novel site on GABA_A receptor.

Technical Data for SCS

M. Wt	256.26
Formula	C₁₄H₁₂N₂O₃
Storage	Store at RT
CAS Number	3232-36-8
PubChem ID	252156309
InChi Key	OMCYEZUIYGPHDJ-OQLLNIDSSA-N
Smiles	OC1=CC=CC=C1\C=N\NC(=O)C1=CC=CC=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for SCS

References are publications that support the biological activity of the product.

Thompson Salicylidene salicylhydrazide, a selective inhibitor of β1-containing GABA_A receptors. Br.J.Pharmacol. 2004 PMID: 15100159

Citations for SCS (2)

Showing 1 - 2 of 2 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for SCS include:

Villumsen et al. (2015) Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Proc Natl Acad Sci U S A. 16:8
PMID: 25887256
Limon et al. (2012) Loss of functional GABA(A) receptors in the Alzheimer diseased brain. J Leukoc Biol. 109:10071
PMID: 22691495

There are no citations that match your criteria.

Showing 1 - 2 of 2 citations Showing All

Product Documents for SCS

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SCS