SB 203186 hydrochloride

Name: SB 203186 hydrochloride
Brand: tocris
SKU: 0785

Catalog # 0785

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:	5-HT₄ antagonist
Chemical Name:	1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	308.81

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Biological Activity

SB 203186 hydrochloride is a potent 5-HT₄ receptor antagonist with high affinity for human atrial 5-HT₄ receptors.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M. Wt	308.81
Formula	C₁₆H₂₀N₂O₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	207572-69-8
PubChem ID	9926639
InChi Key	LYMBEMCUJNDSBZ-UHFFFAOYSA-N
Smiles	Cl.O=C(OCCN1CCCCC1)C1=CNC2=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.24 mL	16.19 mL	32.38 mL
5 mM	0.65 mL	3.24 mL	6.48 mL
10 mM	0.32 mL	1.62 mL	3.24 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

McLean and Coupar 5-HT₄ receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch.Pharmacol. 1995 PMID: 747435
Midhurst and Kaumann Characterisation of 5-HT₄ receptor mediating tachycardia in piglet isolated right atrium. Br.J.Pharmacol. 1993 PMID: 8298790
Parker Blockade of human and porcine myocardial 5-HT₄ receptors by SB 203186. Naunyn Schmiedebergs Arch.Pharmacol. 1995 PMID: 8750913