(S)-(-)-Pindolol

Name: ( S )-(-)-Pindolol
Brand: Tocris Bioscience
SKU: 1060

Tocris Bioscience a Bio-Techne Brand

Catalog # 1060

Citations (1)

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Key Product Details

Description:	β₃ partial agonist; also 5-HT_1A and 5-HT_1B antagonist; more active enantiomer of pindolol (Cat. No. 0994)
Chemical Name:	(S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Purity:	≥99% (HPLC)
Molecular Weight:	248.32

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Biological Activity for (S)-(-)-Pindolol

(S)-(-)-Pindolol is a 5-HT_1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β₃-adrenoceptors. More active enantiomer of pindolol.

Racemate also available.

Technical Data for (S)-(-)-Pindolol

M. Wt	248.32
Formula	C₁₄H₂₀N₂O₂
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	26328-11-0
PubChem ID	688095
InChi Key	JZQKKSLKJUAGIC-NSHDSACASA-N
Smiles	CC(C)NC[C@H](O)COC1=C2C=CNC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (S)-(-)-Pindolol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. HCl		100

Preparing Stock Solutions for (S)-(-)-Pindolol

The following data is based on the product molecular weight 248.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.03 mL	20.14 mL	40.27 mL
5 mM	0.81 mL	4.03 mL	8.05 mL
10 mM	0.40 mL	2.01 mL	4.03 mL
50 mM	0.08 mL	0.40 mL	0.81 mL

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References for (S)-(-)-Pindolol

References are publications that support the biological activity of the product.

Corradetti Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT_1A receptors in the rat brain. Br.J.Pharmacol. 1998 PMID: 9504386
Kalkman β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT_1A receptor agonists. Eur.J.Pharmacol. 1989 PMID: 2576226
Walter Stimulant and blocking effects of optical isomers of pin. on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation. Naunyn Schmiedebergs Arch.Pharmacol. 1984 PMID: 6092972

Citations for (S)-(-)-Pindolol (1)

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Citations are publications that use Bio-Techne products. Selected citations for (S)-(-)-Pindolol include:

Kaya et al. (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Front Neurosci. 329:350
PMID: 19144685

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