S 38093

Name: S 38093
Brand: Tocris Bioscience
SKU: 6778
Price: 84 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 6778

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Selective H₃ antagonist and inverse agonist; also σ₁ receptor antagonist; antinociceptive
Chemical Name:	rel-4-[3-[(3aR,6aS)-Hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	288.39

View Full Technical Details for S 38093

Biological Activity for S 38093

S 38093 is a H₃ antagonist and inverse agonist (K_i values are 8.8, 1.2 and 1.44 μM, at rat, human and mouse, respectively). Exhibits no activity at other histaminergic receptors. Antagonizes agonist action at mouse H₃ receptors (K_B = 0.65 μM). Displays inverse agonist action in cells expressing a high H₃ receptor density, (EC₅₀ values are 9 and 1.7 μM, at human and rat H₃ receptors, respectively). Exhibits antihyperalgesic effect in a mouse diabetic neuropathy model in vivo. Promotes hippocampal neurogenesis in a mouse Alzheimer's disease model. Antinociceptive and procognitive. Also σ₁ receptor antagonist. Exhibits ~30-fold selecitivity for σ₁ over H₃ and occupies σ₁ but not H₃ receptors at procognitive does in mice.

Technical Data for S 38093

M. Wt	288.39
Formula	C₁₇H₂₄N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1403835-45-9
PubChem ID	70941112
InChi Key	MRNMYWNBLVJWKG-GASCZTMLSA-N
Smiles	[H][C@@]12CCC[C@@]1(CN(C2)CCCOC3=CC=C(C(N)=O)C=C3)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for S 38093

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.84	100
	ethanol	14.42	50

Preparing Stock Solutions for S 38093

The following data is based on the product molecular weight 288.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.34 mL	34.68 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.73 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for S 38093

References are publications that support the biological activity of the product.

Riddy Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists. Neuropharmacology 2019 PMID: 30359639
Chaumette Effects of S 38093, an antagonist/inverse agonist of histamine H₃ receptors, in models of neuropathic pain in rats. Eur.J.Pain. 2018 PMID: 28877402
Guilloux S 38093, a histamine H₃ antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci.Rep. 2017 PMID: 28218311

Citations for S 38093

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.