RS 67506 hydrochloride

Name: RS 67506 hydrochloride
Brand: tocris
SKU: 0990

Catalog # 0990

Citations (1)

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Key Product Details

Description:	5-HT₄ partial agonist
Chemical Name:	1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
Molecular Weight:	454.41

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Biological Activity

A potent and selective 5-HT₄ partial agonist, with a pK_i of 8.8 at 5-HT₄ sites in guinea pig striatum, but 1A, 1D, 2A, 2C, D₁, D₂ and M_1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt	454.41
Formula	C₁₈H₂₈ClN₃O₄S.HCl
Storage	Store at RT
CAS Number	168986-61-6
PubChem ID	133075
InChi Key	GFWKWEHKHLTRRF-UHFFFAOYSA-N
Smiles	Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		80

Preparing Stock Solutions

The following data is based on the product molecular weight 454.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.8 mM	2.75 mL	13.75 mL	27.51 mL
4 mM	0.55 mL	2.75 mL	5.50 mL
8 mM	0.28 mL	1.38 mL	2.75 mL
40 mM	0.06 mL	0.28 mL	0.55 mL

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References

References are publications that support the biological activity of the product.

Eglen Pharmacological characterization of two novel and potent 5-HT₄ receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 1995 PMID: 8564196
Eglen Central 5-HT₄ receptors. TiPS 1995 PMID: 8578609
Fontana The effects of novel, selective 5-hydroxytryptamine (5HT)₄ ligands in rat spatial navigation. Neuropharmacology 1997 PMID: 9225295

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for RS 67506 hydrochloride include:

Garavaglia et al. (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci. 11:7
PMID: 20085655

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RS 67506 hydrochloride

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