RS 56812 hydrochloride

Name: RS 56812 hydrochloride
Brand: Tocris Bioscience
SKU: 0988

Tocris Bioscience a Bio-Techne Brand

Catalog # 0988

Citations (1)

COA / SDS

Discontinued Product

0988 has been discontinued. View all 5-HT3 Receptor Agonists products.

Key Product Details

Description:	5-HT₃ partial agonist
Chemical Name:	(R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	347.84

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Biological Activity for RS 56812 hydrochloride

RS 56812 hydrochloride is a highly potent and selective 5-HT₃ partial agonist, with a pK_i at 5-HT₃ receptors in rat brain of 9.6, and greater than 1000-fold selectivity over a wide range of other neurotransmitter receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 56812 hydrochloride

M. Wt	347.84
Formula	C₁₈H₂₁N₃O₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	143339-12-2
PubChem ID	67858205
InChi Key	NHWCYXITJPBOHX-RSAXXLAASA-N
Smiles	O=C(C(N[C@@H]3C(CC4)CCN4C3)=O)C1=CN(C)C2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RS 56812 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	34.78	100
	DMSO	17.39	50

Preparing Stock Solutions for RS 56812 hydrochloride

The following data is based on the product molecular weight 347.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.37 mL	28.75 mL
5 mM	0.57 mL	2.87 mL	5.75 mL
10 mM	0.29 mL	1.44 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for RS 56812 hydrochloride

References are publications that support the biological activity of the product.

Clark N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide: a high affinity 5-HT₃ receptor partial agonist. Bioorg.Med.Chem.Lett.

Citations for RS 56812 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for RS 56812 hydrochloride include:

Otvos et al. (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Mol Psychiatry. 7:2336
PMID: 26114334

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