R 892

Tocris Bioscience a Bio-Techne Brand

Catalog # 3226

Citations (1)

COA / SDS

Discontinued Product

3226 has been discontinued. View all Bradykinin Receptor Antagonists products.

Key Product Details

Description:	Potent and selective B₁ antagonist
Molecular Weight:	1154.37

View Full Technical Details for R 892

Biological Activity for R 892

R 892 is a potent and selective bradykinin B₁ receptor antagonist (ID₅₀ values are 2.8 and > 600 nM at B₁ and B₂ receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

Technical Data for R 892

M. Wt	1154.37
Formula	C₅₈H₈₃N₁₃O₁₂
Single Letter Sequence	KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)
Storage	Desiccate at -20°C
CAS Number	229030-05-1
PubChem ID	10374059
InChi Key	STDZHNYUPODPLD-DDLDLQAOSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@](C)(CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for R 892

Solubility

Soluble to 2mg/ml in water

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References for R 892

References are publications that support the biological activity of the product.

Duka Mechanisms mediating the vasoactive effects of the B₁ receptors of bradykinin. Hypertension 2003 PMID: 14557281
Gobeil Kinin B₁ receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension
Gobeil Structure-activity studies of B₁ receptor related peptide. Hypertension 1996 PMID: 8901831

Citations for R 892 (1)

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Citations are publications that use Bio-Techne products. Selected citations for R 892 include:

Mattis et al. (2014) Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection. J Neurosci. 34:11769
PMID: 25164672

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Product Documents for R 892

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.