QX 222

Name: QX 222
Brand: tocris
SKU: 1043

Catalog # 1043

Citations (2)

Datasheet / COA / SDS

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Key Product Details

Description:	Na⁺ channel blocker
Chemical Name:	2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethaniminium chloride
Molecular Weight:	256.77

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Biological Activity

QX 222 is a sodium channel blocker.

Technical Data

M. Wt	256.77
Formula	C₁₃H₂₁ClN₂O
Storage	Desiccate at RT
CAS Number	5369-00-6
PubChem ID	9795082
InChi Key	WFKXSWWTOZBDME-UHFFFAOYSA-N
Smiles	[Cl-].CC1=CC=CC(C)=C1NC(=O)C[N+](C)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 256.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.89 mL	19.47 mL	38.95 mL
5 mM	0.78 mL	3.89 mL	7.79 mL
10 mM	0.39 mL	1.95 mL	3.89 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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References

References are publications that support the biological activity of the product.

Cuevas and Adams Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells. Br.J.Pharmacol. 1994 PMID: 7517326
Hanck Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study. J.Gen.Physiol. 1994 PMID: 8169596

Citations (2)

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Citations are publications that use Bio-Techne products. Selected citations for QX 222 include:

Li et al. (2005) Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Antimicrob Agents Chemother. 49:388
PMID: 15616319
Slesinger (2001) Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophys J. 80:707
PMID: 11159438

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Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

QX 222

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Key Product Details

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Reconstitution Calculator

References

Citations (2)

Product Datasheets

COA

Certificate of Analysis

SDS

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