(+)-AJ 76 hydrochloride

Name: (+)-AJ 76 hydrochloride
Brand: tocris
SKU: 0678

Catalog # 0678

Datasheet / COA / SDS

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Bio-Techne Corporation

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$35 to United States

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Key Product Details

Description:	Antagonist; preferential action at D₂-like autoreceptors
Chemical Name:	(1S,2R)-cis-5-Methoxy-1-methyl-2-(N-propylamino)tetralin hydrochloride
Molecular Weight:	269.81

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Biological Activity

(+)-AJ 76 hydrochloride is a dopamine receptor antagonist with preferential action at presynaptic receptors (pK_i values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD₃. hD₄, hD_2S, hD_2L and rD₂ receptors respectively).

Technical Data

M. Wt	269.81
Formula	C₁₅H₂₃NO.HCl
Storage	Store at RT
CAS Number	85378-82-1
PubChem ID	13755572
InChi Key	KIRYNZFMOLYYQB-YECZQDJWSA-N
Smiles	Cl.CCCN[C@@H]1CCC2=C(OC)C=CC=C2[C@@H]1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		10

Preparing Stock Solutions

The following data is based on the product molecular weight 269.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.06 mL	185.32 mL	370.63 mL
0.5 mM	7.41 mL	37.06 mL	74.13 mL
1 mM	3.71 mL	18.53 mL	37.06 mL
5 mM	0.74 mL	3.71 mL	7.41 mL

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References

References are publications that support the biological activity of the product.

Johansson Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central DA receptor agonists and antagonists. J.Med.Chem. 1987 PMID: 3560156
Kullingsjo Effects of repeated administration of the preferential DA autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 1991 PMID: 1817961
Millan The role of DA D₃ compared with DA D₂ receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 2004 PMID: 14985929
Waters Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on DA release and metabolism in vivo. Eur.J.Pharmacol. 1994 PMID: 8149975