PK 11195

Name: PK 11195
Brand: Tocris Bioscience
SKU: 0670
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0670

Citations (3)

(1)

COA / SDS

Discontinued Product

0670 has been discontinued. View all Translocator Protein Ligands products.

Key Product Details

Description:	Antagonist at peripheral benzodiazepine receptors
Chemical Name:	1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	352.86

View Full Technical Details for PK 11195

Biological Activity for PK 11195

PK 11195 has high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. Also inhibits the human constitutive androstane receptor (hCAR).

Compound Libraries for PK 11195

PK 11195 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PK 11195

M. Wt	352.86
Formula	C₂₁H₂₁ClN₂O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	85532-75-8
PubChem ID	1345
InChi Key	RAVIZVQZGXBOQO-UHFFFAOYSA-N
Smiles	CCC(C)N(C)C(=O)C1=NC(C2=CC=CC=C2Cl)=C2C=CC=CC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PK 11195

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	17.64	50
	DMSO	17.64	50

Preparing Stock Solutions for PK 11195

The following data is based on the product molecular weight 352.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.67 mL	28.34 mL	56.68 mL
2.5 mM	1.13 mL	5.67 mL	11.34 mL
5 mM	0.57 mL	2.83 mL	5.67 mL
25 mM	0.11 mL	0.57 mL	1.13 mL

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Reconstitution Calculator

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References for PK 11195

References are publications that support the biological activity of the product.

Li The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human androstane receptor. Mol.Pharmacol. 2008 PMID: 18492798
Conway Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and α2-adrenoceptor binding in the hippocampus following transient global forebrain isch Neuroscience 1998 PMID: 9483537
Le Fur Differentiation between two ligands for peripheral benzodiazpine binding sites [³H]-Ro 5-4864 and [³H]-PK11195, by thermodynamic studies. Life Sci. 1983 PMID: 6308375

Citations for PK 11195 (3)

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Citations are publications that use Bio-Techne products. Selected citations for PK 11195 include:

Gut et al. (2013) Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. J Cell Mol Med. 9:97
PMID: 23201900
Anderson et al. (2011) Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett. 202:148
PMID: 21315811
Sutter et al. (2003) Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway. Nat Chem Biol. 89:564
PMID: 12888831

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Customer Reviews for PK 11195 (1)

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A peripheral benzodiazepine receptor (PBR) agonist.

Name: Anonymous

Species: Human

Assay Type: In Vitro

It is a peripheral benzodiazepine receptor (PBR) agonist. It is effective in inhibiting LPS-induced pro-inflammatory cytokines such as IL-1beta and TNF-alpha in microglia culture.

There are no reviews that match your criteria.