Piribedil dihydrochloride

Name: Piribedil dihydrochloride
Brand: tocris
SKU: 1031

Catalog # 1031

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	Dopamine agonist
Chemical Name:	2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	371.27

View Full Technical Details for Piribedil dihydrochloride

Biological Activity

Piribedil dihydrochloride is a direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D₃ subtype, for which it has 20 times higher affinity than for D₂, and possesses no significant affinity for D₁ receptors.

Technical Data

M. Wt	371.27
Formula	C₁₆H₁₈N₄O₂.2HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1451048-94-4
PubChem ID	3038520
InChi Key	VRSRBPOCDOKYKT-UHFFFAOYSA-N
Smiles	Cl.Cl.C(N1CCN(CC1)C1=NC=CC=N1)C1=CC=C2OCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	8.37	25

Preparing Stock Solutions

The following data is based on the product molecular weight 371.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.77 mL	53.87 mL	107.74 mL
1.25 mM	2.15 mL	10.77 mL	21.55 mL
2.5 mM	1.08 mL	5.39 mL	10.77 mL
12.5 mM	0.22 mL	1.08 mL	2.15 mL

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References

References are publications that support the biological activity of the product.

Cagnotto In vitro affinity of piribedil for DA D₃ receptor subtypes, an autoradiographic study. Eur.J.Pharmacol. 1996 PMID: 8905329
Jenne Parkinson's disease: pathological mechanisms and actions of piribedil. J.Neurol. 1992 PMID: 1634907
Offermeier and van Rooyen A comparative study of the locomotor activity effects of apomor. and the 'atypical DA agonists' (piribedil and S36080). Life Sci. 1986 PMID: 3081774
Merck Index

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Piribedil dihydrochloride include:

Rodrigues et al. (2014) Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar DArgic D2 activity after REM sleep deprivation. Front Cell Neurosci. 8:383
PMID: 25520618

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Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Piribedil dihydrochloride

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Key Product Details

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Biological Activity

Technical Data

Solubility

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Reconstitution Calculator

References

Citations (1)

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COA

Certificate of Analysis

SDS

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