[Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂

Name: [Phe 1 Ψ(CH 2 -NH)Gly 2 ]Nociceptin(1-13)NH 2
Brand: Tocris Bioscience
SKU: 1092

Tocris Bioscience a Bio-Techne Brand

Catalog # 1092

Citations (1)

COA / SDS

Discontinued Product

1092 has been discontinued. View all NOP Receptor Agonists products.

Key Product Details

Description:	Selective nociceptin receptor agonist
Molecular Weight:	1367.6

View Full Technical Details for [Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂

Biological Activity

[Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ is a potent agonist of the nociceptin (ORL₁) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA₂ = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).

Technical Data

M. Wt	1367.6
Formula	C₆₁H₁₀₂N₂₂O₁₄
Single Letter Sequence	FGGFTGARKSARK (Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH₂-NH), Lys-13 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	213130-17-7
PubChem ID	6324602
InChi Key	ZHKMSRDIVOXQKP-YILJZHMHSA-N
Smiles	[H]N[C@H](CNCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References

References are publications that support the biological activity of the product.

Okawa Comparison of the effects of [Phe¹ω(CH₂-NH)Gly²-nociceptin-(1-13)NH₂ in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 1999 PMID: 10369464
Guerrini A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 1998 PMID: 9489602
Xu [Phe¹ω(CH₂-NH)Gly²-nociceptin-(1-13)NH₂, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 1998 PMID: 9682833
Guerrini Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 1997 PMID: 9191955

Citations for [Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ (1)

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Citations are publications that use Bio-Techne products. Selected citations for [Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ include:

McLeod et al. (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. J Biol Chem. 132:1175
PMID: 11250866

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COA

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[Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂

Tocris Bioscience a Bio-Techne Brand

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References

Citations for [Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ (1)

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[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2

Tocris Bioscience a Bio-Techne Brand

Key Product Details

Customers also Viewed

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 (1)

Product Documents

COA

Certificate of Analysis

SDS

Bio-Techne Brands

[Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂

Citations for [Phe¹Ψ(CH₂-NH)Gly²]Nociceptin(1-13)NH₂ (1)