PF 06650833

Name: PF 06650833
Brand: Tocris Bioscience
SKU: 6373
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 6373

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Potent and selective IRAK4 inhibitor
Chemical Name:	1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	361.37

View Full Technical Details for PF 06650833

Biological Activity for PF 06650833

PF 06650833 is a potent and selective IRAK4 inhibitor (IC₅₀ = 2 nM). Inhibits LPS-induced TNF-α secretion in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 06650833

M. Wt	361.37
Formula	C₁₈H₂₀FN₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1817626-54-2
PubChem ID	118414016
InChi Key	JKDGKIBAOAFRPJ-ZBINZKHDSA-N
Smiles	CC[C@H]1[C@H](NC([C@H]1F)=O)COC2=NC=CC3=C2C=C(C(C(N)=O)=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06650833

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.14	100

Preparing Stock Solutions for PF 06650833

The following data is based on the product molecular weight 361.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.84 mL	27.67 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PF 06650833

References are publications that support the biological activity of the product.

Lee Discovery of clinical candidate 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a potent, selective inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) J.Med.Chem. 2017 PMID: 28498658

Citations for PF 06650833

Please visit our Instrument Citation Database to search our collection of scientific articles that feature our instruments.

Customer Reviews for PF 06650833 (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

Works well for kinase assay

Name: Scott Scarneo

Species: Human

Assay Type: In Vitro

Easy to use and store. I used this assay for a kinase assay against TAK1 in vitro of purified TAK-TAB1.

There are no reviews that match your criteria.