PCA 4248

Name: PCA 4248
Brand: tocris
SKU: 0571

Catalog # 0571

Citations (4)

Datasheet / COA / SDS

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Key Product Details

Description:	PAF receptor antagonist
Chemical Name:	1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester
Purity:	≥95%
Molecular Weight:	361.46

View Full Technical Details for PCA 4248

Biological Activity

A specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC₅₀ value of 1.05 μM and has no significant activity on Ca²⁺ channels. Active in vivo, antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.

Technical Data

M. Wt	361.46
Formula	C₁₉H₂₃NO₄S
Storage	Desiccate at -20°C
Purity	≥95%
CAS Number	123875-01-4
PubChem ID	4698
InChi Key	DHCNAWNKZMNTIS-UHFFFAOYSA-N
Smiles	COC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCCSC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.14	100
	ethanol	36.14	100

Preparing Stock Solutions

The following data is based on the product molecular weight 361.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.83 mL	27.67 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References

References are publications that support the biological activity of the product.

Fernandez-Gallardo Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies. J.Pharmacol.Exp.Ther. 1990 PMID: 2170626
Sunkel 4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists. J.Med.Chem. 1990 PMID: 2175357
Sunkel 1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies. J.Pharmacol.Exp.Ther. 1990 PMID: 2170624

Citations (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for PCA 4248 include:

Hergott et al. (2015) Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. Mediators Inflamm. 125:3878
PMID: 26426079
Bachi et al. (2012) Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. J Pharmacol Exp Ther. 2012:610371
PMID: 22577252
Garcia et al. (2010) Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. PLoS Pathog. 6:e1001171
PMID: 21079759
Mathison et al. (2004) Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats. Br J Pharmacol. 142:1247
PMID: 15249429

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PCA 4248

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Citations (4)

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