OBAA

Name: OBAA
Brand: Tocris Bioscience
SKU: 0606
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0606

Citations (2)

(1)

COA / SDS

Discontinued Product

0606 has been discontinued. View all Phospholipase Inhibitors products.

Key Product Details

Description:	Phospholipase A₂ inhibitor
Chemical Name:	4-(4-Octadecylphenyl)-4-oxobutenoic acid
Molecular Weight:	428.65

View Full Technical Details for OBAA

Biological Activity for OBAA

OBAA is a potent inhibitor of phospholipase A₂ (IC₅₀ = 70 nM). Reduces bronchospasm in guinea pigs in vivo.

Technical Data for OBAA

M. Wt	428.65
Formula	C₂₈H₄₄O₃
Storage	Desiccate at +4°C
CAS Number	221632-26-4
PubChem ID	5353842
InChi Key	ZBESASFHIWDSCJ-WCWDXBQESA-N
Smiles	CCCCCCCCCCCCCCCCCCC1=CC=C(C=C1)C(=O)\C=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for OBAA

References are publications that support the biological activity of the product.

Kohler Phospholipase A₂ inhibition by alkylbenzoyl acrylic acids. Biochem.Pharmacol. 1992 PMID: 1324685
Kohler Phospholipase-A₂ inhibition by alkylbenzoyl acrylic acids. Agents Actions 1991 PMID: 2058477
Madi Allergen-induced bronchospasm in passively sensitized guinea-pigs - influence of new substances in comparison to reference compounds. Agents Actions 1991 PMID: 2058463

Citations for OBAA (2)

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Citations are publications that use Bio-Techne products. Selected citations for OBAA include:

Kuo et al. (2016) MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery. Am J Physiol Heart Circ Physiol. 310:H71
PMID: 26519030
Bianca et al. (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Nat Commun. 161:1835
PMID: 20825409

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Customer Reviews for OBAA (1)

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used this drug as an inhibitor

Name: Anonymous

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: macrophages

Pretreat mouse macrophage cells with this inhibitor prior to the bacterial stimulation

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Product Documents for OBAA

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.