NPC 15199

Name: NPC 15199
Brand: tocris
SKU: 0675

Catalog # 0675

Datasheet / COA / SDS

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Key Product Details

Description:	Increases intracellular Ca²⁺ levels
Chemical Name:	N-(9-Fluorenylmethoxycarbonyl)-L-leucine
Purity:	≥99% (HPLC)

View Full Technical Details for NPC 15199

Biological Activity

Anti-inflammatory agent; increases intracellular Ca²⁺ levels.

Technical Data

M. Wt	353.42
Formula	C₂₁H₂₃NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	35661-60-0
PubChem ID	1549477
InChi Key	CBPJQFCAFFNICX-LJQANCHMSA-N
Smiles	O=C(N[C@H](CC(C)C)C(O)=O)OCC1C(C=CC=C3)=C3C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.34	100 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 353.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.29 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.41 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Burch N-(Fluorenyl-9-methoxycarbonyl) amino acids, a class of anti-inflammatory agents with a different mechanism of action. Proc.Natl.Acad.Sci.U.S.A. 1991 PMID: 1824872
Jan NPC-15199, a novel anti-inflammatory agent, mobilizes intracellular Ca²⁺ in bladder female transitional carcinoma (BFTC) cells. Chin.J.Physiol. 2000 PMID: 10857466
Miller Guinea pig ileitis is attenuated by the leumidin N-(fluorenyl-9-methoxycarbonyl)leucine (NPC 15199). J.Pharmacol.Exp.Ther. 1993 PMID: 8392562