K_ir6 (K_ATP) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K_ir6 channels (EC₅₀ values are 10 and > 500 μM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.

Technical Data

M. Wt	211.18
Formula	C₈H₉N₃O₄
Storage	Desiccate at +4°C
CAS Number	65141-46-0
PubChem ID	47528
InChi Key	LBHIOVVIQHSOQN-UHFFFAOYSA-N
Smiles	[O-][N+](=O)OCCNC(=O)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble Soluble to 20 mM in water

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References

References are publications that support the biological activity of the product.

Shindo SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K⁺ channels by pinacidil and nicorandil. Br.J.Pharmacol. 1998 PMID: 9692785
Horinaka Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J.Cardiovasc.Pharmacol. 2001 PMID: 11483869
Gomma Potassium channel openers in myocardial ischaemia: therapeutic potential of nicorandil. Drugs 2001 PMID: 11693460

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Nicorandil include:

Killeen et al. (2008) Effects of potassium channel openers in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf). 193:25
PMID: 18005217

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Nicorandil was used to study Kca1.1 channels

Name: Sadequl Islam

Species: Human

Assay Type: In Vitro

Nicorandil was used to study Kca1.1 channels which are are voltage-gated potassium channels that conduct large amounts of potassium ions (K+) across the cell membrane. To understand neuronal excitability modulated by BK channel opening, Nicorandil was introduced into the cell line.

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Nicorandil

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Biological Activity