Nicergoline

Name: Nicergoline
Brand: tocris
SKU: 0604

Catalog # 0604

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	α antagonist
Chemical Name:	(8β)-10-methoxy-1,6-dimethylergoline-8-methanol 5-bromo-3-pyridine carboxylate ester
Molecular Weight:	484.39

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Biological Activity

Nicergoline is a α-adrenergic, vasodilator. Cognitive enhancer.

Technical Data

M. Wt	484.39
Formula	C₂₄H₂₆BrN₃O₃
Storage	Store at RT
CAS Number	27848-84-6
PubChem ID	90479736
InChi Key	GCNGMFQQSBSPIJ-XPXYHQFPSA-N
Smiles	[H][C@](COC(C5=CN=CC(Br)=C5)=O)1C[C@@](C2=CC=CC3C2C(C4)=CN3C)(OC)[C@]4([H])N(C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	48.43	100

Preparing Stock Solutions

The following data is based on the product molecular weight 484.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.06 mL	10.32 mL	20.64 mL
5 mM	0.41 mL	2.06 mL	4.13 mL
10 mM	0.21 mL	1.03 mL	2.06 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References

References are publications that support the biological activity of the product.

Carfagna Modulation of hippocampal ACh release by chronic nicergoline treatment in freely moving young and aged rats. Neurosci.Lett. 1995 PMID: 8552297
Carfagna Modulation of phosphoinositide turnover by chronic nicergoline in rat brain. Neurosci.Lett. 1996 PMID: 8736642
Chopin and Briley Effects of four non-cholinergic cognitive enhancers in comparison with tac. and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology 1992 PMID: 1738791
Merck Index

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Nicergoline include:

Woo et al. (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 54:599
PMID: 17521572

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Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Nicergoline

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Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

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