Naloxonazine dihydrochloride

Name: Naloxonazine dihydrochloride
Brand: tocris
SKU: 0591

Catalog # 0591

Citations (4)

Datasheet / COA / SDS

Discontinued Product

0591 has been discontinued. View all mu Opioid Receptor Antagonists products.

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Key Product Details

Description:	Selective μ₁ antagonist
Chemical Name:	Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	723.69

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Biological Activity

Naloxonazine dihydrochloride is a potent opioid antagonist, selective for μ₁ receptors.

Technical Data

M. Wt	723.69
Formula	C₃₈H₄₂N₄O₆.2HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	880759-65-9
PubChem ID	90479735
InChi Key	VIAIHLLKDJKEKM-DCBBKWFGSA-N
Smiles	[H][C@@]12OC3=C(C=CC4=C3[C@@]15CCN([C@](C4)([C@@]5(CC/C2=N\N=C6CC[C@]7([C@]8(CC9=C%10C(O[C@@]/6([C@@]7%10CCN8CC=C)[H])=C(C=C9)O)[H])O)O)[H])CC=C)O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		25

Preparing Stock Solutions

The following data is based on the product molecular weight 723.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	5.53 mL	27.64 mL	55.27 mL
1.25 mM	1.11 mL	5.53 mL	11.05 mL
2.5 mM	0.55 mL	2.76 mL	5.53 mL
12.5 mM	0.11 mL	0.55 mL	1.11 mL

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References

References are publications that support the biological activity of the product.

Paul Differential blockade by naloxonazine of two μ opiate actions: analgesic and inhibition of gastrointestinal transit. Eur.J.Pharmacol. 1988 PMID: 2842168

Citations (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Naloxonazine dihydrochloride include:

Smith et al. (2016) Endogenous central amygdala mu-opioid receptor signaling promotes sodium appetite in mice. Proc Natl Acad Sci U S A. 113:13893
PMID: 27849613
Gerhold et al. (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 35:9580
PMID: 26134641
Yi et al. (2015) Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. BMC Cell Biol. 22:49
PMID: 26150021
Lee et al. (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Biomed Sci. 2012:941685
PMID: 22645476

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Showing 1 - 4 of 4 citations Showing All

Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Naloxonazine dihydrochloride

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Biological Activity

Technical Data

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Reconstitution Calculator

References

Citations (4)

Product Datasheets

COA

Certificate of Analysis

SDS

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