Naftopidil hydrochloride

Name: Naftopidil hydrochloride
Brand: Tocris Bioscience
SKU: 0597

Tocris Bioscience a Bio-Techne Brand

Catalog # 0597

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Key Product Details

Description:	α₁ antagonist
Chemical Name:	4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	428.96

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Biological Activity for Naftopidil hydrochloride

An α₁-adrenoceptor antagonist with only weak antagonism at post-junctional α₂ receptors; a potent, persistent antihypertensive and vasodilator.

Technical Data for Naftopidil hydrochloride

M. Wt	428.96
Formula	C₂₄H₂₈N₂O₃.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1164469-60-6
PubChem ID	6603044
InChi Key	VQAAEWMEVIOHTJ-UHFFFAOYSA-N
Smiles	Cl.COC1=C(C=CC=C1)N1CCN(CC(O)COC2=C3C=CC=CC3=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Naftopidil hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.9	100

Preparing Stock Solutions for Naftopidil hydrochloride

The following data is based on the product molecular weight 428.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.66 mL	23.31 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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Reconstitution Calculator

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References for Naftopidil hydrochloride

References are publications that support the biological activity of the product.

Muramatsu Pharmacological profile of the novel alpha-adrenoceptor antagonist KT-611 (naftopidil). Jpn.J.Pharmacol. 1991 PMID: 1677438
Borbe and Peter Alpha-1-adrenoceptor-binding material in rat plasma following single oral administration of naftopidil. Arzneimittelforschung 1990 PMID: 1971750

Citations for Naftopidil hydrochloride

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