Naftopidil hydrochloride

Name: Naftopidil hydrochloride
Brand: tocris
SKU: 0597

Catalog # 0597

Datasheet / COA / SDS

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Bio-Techne Corporation

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Key Product Details

Description:	α₁ antagonist
Chemical Name:	4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	428.96

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Biological Activity

An α₁-adrenoceptor antagonist with only weak antagonism at post-junctional α₂ receptors; a potent, persistent antihypertensive and vasodilator.

Technical Data

M. Wt	428.96
Formula	C₂₄H₂₈N₂O₃.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1164469-60-6
PubChem ID	6603044
InChi Key	VQAAEWMEVIOHTJ-UHFFFAOYSA-N
Smiles	Cl.COC1=C(C=CC=C1)N1CCN(CC(O)COC2=C3C=CC=CC3=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.9	100

Preparing Stock Solutions

The following data is based on the product molecular weight 428.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.66 mL	23.31 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Borbe and Peter Alpha-1-adrenoceptor-binding material in rat plasma following single oral administration of naftopidil. Arzneimittelforschung 1990 PMID: 1971750
Muramatsu Pharmacological profile of the novel alpha-adrenoceptor antagonist KT-611 (naftopidil). Jpn.J.Pharmacol. 1991 PMID: 1677438