MRS 5698

Name: MRS 5698
Brand: Tocris Bioscience
SKU: 5428
Price: 468 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 5428

Citations (1)

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Key Product Details

Description:	High affinity and selective A₃ agonist
Chemical Name:	(1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	564.97

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Biological Activity for MRS 5698

MRS 5698 is a high affinity and selective A₃ adenosine receptor agonist (K_i ~ 3 nM); displays >1000-fold selectivity over A₁ and A_2A adenosine receptors. Reverses mechanoallodynia in several neuropathic pain models in vivo. Orally bioavailable.

Technical Data for MRS 5698

M. Wt	564.97
Formula	C₂₈H₂₃ClF₂N₆O₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1377273-00-1
PubChem ID	57523213
InChi Key	LYLLLJJYBWLGHW-CIZVZKTGSA-N
Smiles	O=[C@](NC)[C@@]1(C2)[C@H]2[C@@H](N3C(N=C(C#CC6=CC(F)=C(F)C=C6)N=C4NCC5=CC(Cl)=CC=C5)=C4N=C3)[C@H](O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 5698

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	5.65	10

Preparing Stock Solutions for MRS 5698

The following data is based on the product molecular weight 564.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.70 mL	88.50 mL	177.00 mL
0.5 mM	3.54 mL	17.70 mL	35.40 mL
1 mM	1.77 mL	8.85 mL	17.70 mL
5 mM	0.35 mL	1.77 mL	3.54 mL

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References for MRS 5698

References are publications that support the biological activity of the product.

Little Endogenous adenosine A₃ receptor activation selectively alleviates persistent pain states. Brain 2015 PMID: 25414036
Tosh Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A₃ adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 2015 PMID: 26111639
Tosh Structure-guided design of A₃ adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions. J.Med.Chem. 2012 PMID: 22559880

Citations for MRS 5698 (1)

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Citations are publications that use Bio-Techne products. Selected citations for MRS 5698 include:

Fong et al. (2019) Antitumor effects of MRS5698, a cordycepin derivative, on endometrial cancer cells Natural Product Communications. 14:1
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Product Documents for MRS 5698

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.