MPC 6827 hydrochloride

Name: MPC 6827 hydrochloride
Brand: Tocris Bioscience
SKU: 5231

Catalog # 5231 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Inhibitor of microtubule polymerization; antimitotic and antitumor

Key Product Details

Description:	Inhibitor of microtubule polymerization; antimitotic and antitumor
Chemical Name:	N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	315.8

View Full Technical Details for MPC 6827 hydrochloride

Technical Data
Citations (2) / Reviews

Biological Activity for MPC 6827 hydrochloride

MPC 6827 hydrochloride is a potent inhibitor of microtubule formation (IC₅₀ = 1.5 - 3.4 nM); inhibits polymerization of tubulin in vitro and disrupts microtubule formation in several cancer cell lines. Inhibits tumor growth in vitro and in vivo; exhibits pro-apoptotic characteristics. Brain penetrant.

Technical Data for MPC 6827 hydrochloride

M. Wt	315.8
Formula	C₁₇H₁₇N₃O.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	917369-31-4
PubChem ID	11638255
InChi Key	VYUWDIKZJLOZJL-UHFFFAOYSA-N
Smiles	CC2=NC1=CC=CC=C1C(N(C)C3=CC=C(OC)C=C3)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MPC 6827 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.58	100
	DMSO	31.58	100

Preparing Stock Solutions for MPC 6827 hydrochloride

The following data is based on the product molecular weight 315.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.17 mL	15.83 mL	31.67 mL
5 mM	0.63 mL	3.17 mL	6.33 mL
10 mM	0.32 mL	1.58 mL	3.17 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for MPC 6827 hydrochloride

References are publications that support the biological activity of the product.

Mahal Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels. ChemMedChem. 2014 PMID: 24678059
Sirisoma Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration. J.Med.Chem. 2009 PMID: 19296653
Kasibhatla MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 PMID: 17575155

Citations for MPC 6827 hydrochloride (2)

Showing 1 - 2 of 2 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for MPC 6827 hydrochloride include:

Christopher T et al. (2022) Initial Evaluations of the Microtubule-Based PET Radiotracer, [11C]MPC-6827 in a Rodent Model of Cocaine Abuse. Front Med (Lausanne). 9:817274
PMID: 35295607
Suzanne et al. (2022) Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Res. 12:41
PMID: 35881263

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