Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: Tocris Bioscience
SKU: 3286

Tocris Bioscience a Bio-Techne Brand

Catalog # 3286

Citations (1)

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Key Product Details

Description:	5-HT and NA reuptake inhibitor (SNRI)
Chemical Name:	(1R,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	282.81

View Full Technical Details for Milnacipran hydrochloride

Biological Activity for Milnacipran hydrochloride

Milnacipran hydrochloride is a orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC₅₀ values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α₁-adrenergic and 5-HT_2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo.

Technical Data for Milnacipran hydrochloride

M. Wt	282.81
Formula	C₁₅H₂₂N₂O.HCl
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	101152-94-7
PubChem ID	73416954
InChi Key	GIGAIOSMEXBLQA-IBWNGBJLSA-N
Smiles	NC[C@@H]1[C@@]([C@](N(CC)CC)=O)([C@]2=CC=CC=C2)C1.NC[C@H]3[C@]([C@](N(CC)CC)=O)([C@]4=CC=CC=C4)C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Milnacipran hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.28	100
	DMSO	28.28	100

Preparing Stock Solutions for Milnacipran hydrochloride

The following data is based on the product molecular weight 282.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.68 mL	35.36 mL
5 mM	0.71 mL	3.54 mL	7.07 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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References for Milnacipran hydrochloride

References are publications that support the biological activity of the product.

Suzuki Antiallodynic and antihyperalgesic effect of milnac. in mice with spinal nerve ligation. Anesth.Analg. 2008 PMID: 18349211
Maj Pharmacological effect of milnacipran, a new antidepressant, given repeatedly on the α₁-adrenergic and serotonergic 5-HT_2A systems. J.Neural.Transm. 2000 PMID: 11145008
Moret Biochemical profile of midalcipran (F 2207), 1-phenyl-1-diethyl-aminocarbonyl-2-aminomethyl-cyclopropane (z) hydrochloride, a potential fourth generation antidepressant drug. Neuropharmacology 1985 PMID: 3005901

Citations for Milnacipran hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for Milnacipran hydrochloride include:

Burnham and Dickenson (2013) The antinociceptive effect of milnac. in the monosodium iodoacetate model of osteoarthritis pain and its relation to changes in descending inhibition. J Pharmacol Exp Ther. 344:696
PMID: 23297162

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Product Documents for Milnacipran hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.