Mianserin hydrochloride

Name: Mianserin hydrochloride
Brand: Tocris Bioscience
SKU: 0997

Tocris Bioscience a Bio-Techne Brand

Catalog # 0997

Citations (2)

COA / SDS

Discontinued Product

0997 has been discontinued. View all Non-selective 5-HT2 Receptor Antagonists products.

Key Product Details

Description:	5-HT₂ antagonist. Has moderate affinity for 5-HT₆
Chemical Name:	1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	300.83

View Full Technical Details for Mianserin hydrochloride

Biological Activity for Mianserin hydrochloride

Mianserin hydrochloride is a non-selective 5-HT₂ receptor antagonist (K_i values are 0.0080 and 0.0081 μM for human 5-HT_2A and 5-HT_2C receptors expressed in HEK293 cells respectively). Has moderate affinity for 5-HT₆. Antidepressant.

Technical Data for Mianserin hydrochloride

M. Wt	300.83
Formula	C₁₈H₂₀N₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	21535-47-7
PubChem ID	68551
InChi Key	YNPFMWCWRVTGKJ-UHFFFAOYSA-N
Smiles	Cl.CN1CCN2C(C1)C1=CC=CC=C1CC1=C2C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Mianserin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	3.01	10

Preparing Stock Solutions for Mianserin hydrochloride

The following data is based on the product molecular weight 300.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.24 mL	166.21 mL	332.41 mL
0.5 mM	6.65 mL	33.24 mL	66.48 mL
1 mM	3.32 mL	16.62 mL	33.24 mL
5 mM	0.66 mL	3.32 mL	6.65 mL

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References for Mianserin hydrochloride

References are publications that support the biological activity of the product.

Jensen Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 2013 PMID: 23301527
Hoyer VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 1994 PMID: 7938165
Leonard On the mode of action of mianserin. Adv.Biochem.Psychopharmacol. 1982 PMID: 6282060

Citations for Mianserin hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Mianserin hydrochloride include:

Wei et al. (2010) JNK regulates serotonin-mediated proliferation and migration of pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 298:L863
PMID: 20228179
Mbaki (2008) Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat. Br J Pharmacol. 155:343
PMID: 18604238

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Product Documents for Mianserin hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.