MG 624

Name: MG 624
Brand: Tocris Bioscience
SKU: 1356
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1356

Citations (3)

(1)

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Key Product Details

Description:	α7 neuronal nAChR antagonist
Chemical Name:	N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide
Purity:	≥98% (HPLC)
Molecular Weight:	451.39

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Biological Activity for MG 624

MG 624 is a selective antagonist for neuronal α7 subunit- containing nAChR subtypes. Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with K_i values of 106 nM and 84 μM respectively.

Technical Data for MG 624

M. Wt	451.39
Formula	C₂₂H₃₀NOI
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	77257-42-2
PubChem ID	6433339
InChi Key	RDTKUZXIHMTSJO-UEIGIMKUSA-M
Smiles	[I-].CC[N+](CC)(CC)CCOC1=CC=C(\C=C\C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MG 624

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.03	20
	ethanol		10

Preparing Stock Solutions for MG 624

The following data is based on the product molecular weight 451.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.08 mL	55.38 mL	110.77 mL
1 mM	2.22 mL	11.08 mL	22.15 mL
2 mM	1.11 mL	5.54 mL	11.08 mL
10 mM	0.22 mL	1.11 mL	2.22 mL

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References for MG 624

References are publications that support the biological activity of the product.

Maggi Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick α7 nicotinic receptor. Br.J.Pharmacol. 1999 PMID: 10051147
Gotti 4-Oxystilbene compounds are selective ligands for neuronal nicotinic abungarotoxin receptors. Br.J.Pharmacol. 1998 PMID: 9720791

Citations for MG 624 (3)

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Citations are publications that use Bio-Techne products. Selected citations for MG 624 include:

Cassilly et al. (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Int J Clin Exp Pathol. 11:e0154932
PMID: 27183222
Dolma et al. (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell. 29:859
PMID: 27300435
Chang et al. (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep. 5:10256
PMID: 26194093

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The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound

Name: Anonymous

Species: Other

Assay Type: In Vitro

Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience

PMID: 27183222

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Product Documents for MG 624

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.