Tocris Bioscience a Bio-Techne Brand
Key Product Details
|Description:||5-HT2 antagonist. Also 5-HT1 antagonist and 5-HT1D ligand. Has moderate affinity for 5-HT6 and high affinity for 5-HT7|
|Chemical Name:||[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester|
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Citations for Metergoline (4)
Citations are publications that use Bio-Techne products. Selected citations for Metergoline include:
Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptoractivation and NE reuptake inhibition.
Chan et al.
A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.
Lee et al.
Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes.
Acta Pharmacol Sin.
Woo et al.
Neuregulin-1 enhances depolarization-induced GABA release.
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Customer Reviews for Metergoline (1)
Species: MouseAssay Type: In Vivodissolved fine in DMSO, but came out of solution as soon as I added any saline. Would not stay in solution at even 50% DMSO in saline, it precipitated out into a fluffy white solid (picture attached). Also tried to dissolve in 1% ascorbic acid, and that didn't work either (1mg/ml). Also could not dissolve in 10% ascorbic acid (1mg/ml). I tried heating, vortexing, and sonicating with both and could not get it into solution. could not use with with my experimentsTocris reply: We're sorry to hear that you have experienced problems with the solubility of Metergoline. We would like to make you aware of the following publication where metergoline 10 mg was solubilized in 1 ml of 45% w/v 2‐hydroxypropyl‐ beta ‐cyclodextrin in H2O and the solution lyophilized to form a fully soluble powder (Negri et al., 1998. PMID: 9641552). The powder (460 mg) was then dissolved in 30 ml of saline and injected in a volume of 1–6 ml kg−1 (s.c). We would like to offer a replacement vial if you no longer have any remaining material for attempting this solubilization method. If this is of interest, please contact us at firstname.lastname@example.org.
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