Metergoline

Name: Metergoline
Brand: Tocris Bioscience
SKU: 0590
Rating: 1 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 0590

Citations (4)

(1)

COA / SDS

Discontinued Product

0590 has been discontinued. View all Non-selective 5-HT2 Receptor Antagonists products.

Key Product Details

Description:	5-HT₂ antagonist. Also 5-HT₁ antagonist and 5-HT_1D ligand. Has moderate affinity for 5-HT₆ and high affinity for 5-HT₇
Chemical Name:	[(8β)-1,6-Dimethylergolin-8-yl)methyl]carbamic acid phenylmethyl ester
Molecular Weight:	403.52

View Full Technical Details for Metergoline

Biological Activity for Metergoline

Metergoline is an antagonist at 5-HT₁/5-HT₂ with activity at 5-HT_1D. Has moderate affinity for 5-HT₆ and high affinity for 5-HT₇.

Technical Data for Metergoline

M. Wt	403.52
Formula	C₂₅H₂₉N₃O₂
Storage	Store at RT
CAS Number	17692-51-2
PubChem ID	28693
InChi Key	WZHJKEUHNJHDLS-QTGUNEKASA-N
Smiles	[H][C@](CNC(OCC5=CC=CC=C5)=O)1C[C@@](C2=CC=CC3=C2C(C4)=CN3C)([H])[C@]4([H])N(C1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Metergoline

References are publications that support the biological activity of the product.

Negri Respiratory and cardiovascular effects of the mu-opioid receptor agonist [Lys⁷]dermorphin in awake rats. Br.J.Pharmacol. 1998 PMID: 9641552
Aulakh Effects of various serotonin receptor subtype selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. J.Pharmacol.Exp.Ther. 1992 PMID: 1432690
Bagdy Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur.J.Pharmacol. 1992 PMID: 1535317
Miller Agonist activity of sumatr. and metergoline at the human 5-HT_1Dβ receptor in the action of sumatr. Eur.J.Pharmacol. 1992 PMID: 1330643

Citations for Metergoline (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Metergoline include:

Wang (2017) Dezocine exhibits antihypersensitivity activities in neuropathy through spinal μ-opioid receptoractivation and NE reuptake inhibition. Sci Rep. 7:43137
PMID: 28230181
Chan et al. (2016) A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors. PLoS Pathog. 12:e1005651
PMID: 27187180
Lee et al. (2014) Metergoline inhibits the neuronal Nav1.2 voltage-dependent Na(+) channels expressed in Xenopus oocytes. Acta Pharmacol Sin. 35:862
PMID: 24909513
Woo et al. (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron. 54:599
PMID: 17521572

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Customer Reviews for Metergoline (1)

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Could not dissolve for in vivo use

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

dissolved fine in DMSO, but came out of solution as soon as I added any saline. Would not stay in solution at even 50% DMSO in saline, it precipitated out into a fluffy white solid (picture attached). Also tried to dissolve in 1% ascorbic acid, and that didn't work either (1mg/ml). Also could not dissolve in 10% ascorbic acid (1mg/ml). I tried heating, vortexing, and sonicating with both and could not get it into solution. could not use with with my experiments

Tocris reply: We're sorry to hear that you have experienced problems with the solubility of Metergoline. We would like to make you aware of the following publication where metergoline 10 mg was solubilized in 1 ml of 45% w/v 2‐hydroxypropyl‐ beta ‐cyclodextrin in H2O and the solution lyophilized to form a fully soluble powder (Negri et al., 1998. PMID: 9641552). The powder (460 mg) was then dissolved in 30 ml of saline and injected in a volume of 1–6 ml kg−1 (s.c). We would like to offer a replacement vial if you no longer have any remaining material for attempting this solubilization method. If this is of interest, please contact us at techsupport@bio-techne.com.

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Product Documents for Metergoline

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.