LY 225910

Name: LY 225910
Brand: Tocris Bioscience
SKU: 1018

Catalog # 1018

Citations (3)

COA / SDS

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$35 to United States

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Key Product Details

Description:	Potent CCK₂ antagonist
Chemical Name:	2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline
Molecular Weight:	502.41

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Biological Activity

LY 225910 is a potent CCK₂ receptor antagonist (IC₅₀ = 9.3 nM for inhibition of ¹²⁵I-labeled CCK-8 sulfate binding at mouse brain membranes).

Licensing Information

Sold with the permission of Eli Lilly and Company.

Technical Data

M. Wt	502.41
Formula	C₂₇H₂₄BrN₃O₂
Storage	Desiccate at -20°C
CAS Number	133040-77-4
PubChem ID	4355450
InChi Key	KUECXUACQOYKNB-UHFFFAOYSA-N
Smiles	CC(C)OC1=CC=CC(=C1)N1C(CCC2=CNC3=CC=C(Br)C=C23)=NC2=C(C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions

The following data is based on the product molecular weight 502.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.99 mL	9.95 mL	19.90 mL
5 mM	0.40 mL	1.99 mL	3.98 mL
10 mM	0.20 mL	1.00 mL	1.99 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References

References are publications that support the biological activity of the product.

Suman-Chauhan The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B / gastrin receptors: binding studies using [³H]PD140376. Regul.Pept. 1996 PMID: 8876034
Yu Quinazolinone cholecystokinin receptor ligands. J.Med.Chem. 1991 PMID: 2016728

Citations for LY 225910 (3)

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Citations are publications that use Bio-Techne products. Selected citations for LY 225910 include:

Seillier et al. (2013) Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB1 receptors: implications for schizophrenia. Neuropharmacology. 38:1816
PMID: 23563893
Karson et al. (2008) Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others. J Card Fail. 54:117
PMID: 17689570
Gallopin et al. (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. Neuropsychopharmacology. 16:1440
PMID: 16339088

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