L-AP6

Name: L-AP6
Brand: tocris
SKU: 0341

Catalog # 0341

Datasheet / COA / SDS

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Key Product Details

Description:	Selective agonist of the 'quis' effect
Chemical Name:	L-(+)-2-Amino-6-phosphonohexanoic acid
Molecular Weight:	211.15

View Full Technical Details for L-AP6

Technical Data
Citations / Reviews

Biological Activity

Selective agonist for 'quis'-sensitized site.

Technical Data

M. Wt	211.15
Formula	C₆H₁₄NO₅P
Storage	Store at RT
CAS Number	78944-89-5
PubChem ID	3062646
InChi Key	QIOXWRQXHFVNLV-YFKPBYRVSA-N
Smiles	[H][C@@](CCCCP(O)(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions

The following data is based on the product molecular weight 211.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.74 mL	23.68 mL	47.36 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.74 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Johansen Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats. Mol.Pharmacol. 1995 PMID: 7623768
Schulte Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
Venkatraman Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus. J.Med.Chem. 1994 PMID: 7966155